IntEnz

EC 1.13.11.57 - Gallate dioxygenase

IntEnz Enzyme Nomenclature
EC 1.13.11.57

Names

Reaction

• 28927 [IUBMB]
  3,4,5-trihydroxybenzoate

  3,4,5-trihydroxybenzoate

  Name origin: UniProt - CHECKED (C)

  CHEBI:16918

  Formula: C7H5O5
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  O₂

  O2

  Name origin: UniProt - CHECKED (C)

  CHEBI:15379

  Formula: O2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate

  (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate

  Name origin: UniProt - CHECKED (C)

  CHEBI:57471

  Formula: C7H3O7
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  +

  2

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Cofactor

• Fe cation

Comments:

Contains non-heme Fe²⁺. The enzyme is a ring-cleavage dioxygenase that acts specifically on gallate to produce the keto-tautomer of 4-oxalomesaconate [1,2].

Links to other databases

References

1. Nogales, J., Canales, A., Jimenez-Barbero, J., Garcia, J. L., Diaz, E.
   Molecular characterization of the gallate dioxygenase from Pseudomonas putida KT2440. The prototype of a new subgroup of extradiol dioxygenases.
   J. Biol. Chem. 280: 35382-35390 (2005). [PMID: 16030014]
2. Nogales, J., Canales, A., Jimenez-Barbero, J., Serra, B., Pingarron, J. M., Garcia, J. L., Diaz, E.
   Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
   Mol. Microbiol. 79: 359-374 (2011). [PMID: 21219457]

[EC 1.13.11.57 created 2011]