EC 1.13.11.46 - 4-hydroxymandelate synthase

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IntEnz Enzyme Nomenclature
EC 1.13.11.46

Names

Accepted name:
4-hydroxymandelate synthase
Other name:
4-hydroxyphenylpyruvate dioxygenase II
Systematic name:
(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)

Reaction

Cofactor

Comments:

Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050585
UniProtKB/Swiss-Prot:

References

  1. Choroba, O.W., Williams, D.H. and Spencer, J.B.
    Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine.
    J. Am. Chem. Soc. 122 : 5389-5390 (2000).
  2. Hubbard, B. K., Thomas, M. G., Walsh, C. T.
    Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
    Chem. Biol. 7 : 931-942 (2000). [PMID: 11137816]

[EC 1.13.11.46 created 2001]