EC 1.13 - Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2
EC 220.127.116.11 - 4-hydroxymandelate synthase
IntEnz view ENZYME view
IntEnz Enzyme Nomenclature
4-hydroxyphenylpyruvate dioxygenase II
(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
21376 [IUBMB]3-(4-hydroxyphenyl)pyruvate3-(4-hydroxyphenyl)pyruvateName origin: UniProt - CHECKED (C)Formula: C9H7O4
Charge: -1ChEBI compound status: CHECKED (C)O2O2Name origin: UniProt - CHECKED (C)Formula: O2
Charge: 0ChEBI compound status: CHECKED (C)=(S)-4-hydroxymandelate(S)-4-hydroxymandelateName origin: UniProt - CHECKED (C)Formula: C8H7O4
Charge: -1ChEBI compound status: CHECKED (C)
Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.
Links to other databases
Gene Ontology: GO:0050585
Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine.J. Am. Chem. Soc. 122 : 5389-5390 (2000).
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.Chem. Biol. 7 : 931-942 (2000). [PMID: 11137816]
[EC 18.104.22.168 created 2001]