EC - Arachidonate 5-lipoxygenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
arachidonate 5-lipoxygenase
Other names:
LTA synthase
arachidonic 5-lipoxygenase
arachidonic acid 5-lipoxygenase
leukotriene A4 synthase
leukotriene-A4 synthase
Systematic name:
arachidonate:oxygen 5-oxidoreductase



Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00077
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004051
CAS Registry Number: 80619-02-9


  1. Matsumoto, T., Funk, C.D., Radmark, O., Hoog, J.-O., Jornvall, H. and Samuelsson, B.
    Molecular cloning and amino acid sequence of human 5-lipoxygenase.
    Proc. Natl. Acad. Sci. USA 85: 26-30 (1988). [PMID: 2829172]
  2. Ohishi, N., Izumi, T., Minami, M., Kitamura, S., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F. and Shimizu, T.
    Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers.
    J. Biol. Chem. 262: 10200-10205 (1987). [PMID: 3038871]
  3. Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., Rädmark, O. and Samuelsson, B.
    Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase.
    Proc. Natl. Acad. Sci. USA 83: 4175-4179 (1986). [PMID: 3012557]
  4. Shimizu, T., Rädmark, O. and Samuelssohn, B.
    Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.
    Proc. Natl. Acad. Sci. USA 81: 689-693 (1984). [PMID: 6322165]

[EC created 1984, modified 1990]