EC 1 - Oxidoreductases
EC 1.13 - Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2
EC 1.13.11 - With incorporation of two atoms of oxygen
EC 1.13.11.33 - Arachidonate 15-lipoxygenase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.13.11.33
Names
Accepted name:
arachidonate 15-lipoxygenase
Other
names:
15-lipoxygenase
ω6 lipoxygenase
linoleic acid ω6-lipoxygenase
ω6 lipoxygenase
linoleic acid ω6-lipoxygenase
Systematic name:
arachidonate:oxygen 15-oxidoreductase
Reaction
- arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
Cofactor
Comments:
The product is rapidly reduced to the corresponding 15S-hydroxy compound.
Links to other databases
Protein domains and families:
PROSITE:PDOC00077
Gene Ontology:
GO:0050473
CAS Registry Number:
82249-77-2
References
-
Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid.J. Biol. Chem. 257 : 6050-6055 (1982). [PMID: 6804460]
-
Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes.Methods Enzymol. 86 : 45-48 (1982). [PMID: 6813644]
-
Metabolism of polyunsaturated fatty acids by an (n-6)-lipoxygenase associated with human ejaculates.Biochim. Biophys. Acta 1002 : 283-291 (1989). [PMID: 2496760]
-
Primary structure of soybean lipoxygenase-1.J. Biol. Chem. 262 : 10080-10085 (1987). [PMID: 3112136]
[EC 1.13.11.33 created 1984]