EC - Arachidonate 15-lipoxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
arachidonate 15-lipoxygenase
Other names:
ω6 lipoxygenase
linoleic acid ω6-lipoxygenase
Systematic name:
arachidonate:oxygen 15-oxidoreductase




The product is rapidly reduced to the corresponding 15S-hydroxy compound.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00077
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050473
CAS Registry Number: 82249-77-2
UniProtKB/Swiss-Prot: (17) [show] [UniProt]


  1. Bryant, R.W., Bailey, J.M., Schewqe, T. and Rapoport, S.M.
    Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid.
    J. Biol. Chem. 257 : 6050-6055 (1982). [PMID: 6804460]
  2. Narumiya, S. and Salmon, J.A.
    Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes.
    Methods Enzymol. 86 : 45-48 (1982). [PMID: 6813644]
  3. Oliw, E.H. and Sprecher, H.
    Metabolism of polyunsaturated fatty acids by an (n-6)-lipoxygenase associated with human ejaculates.
    Biochim. Biophys. Acta 1002 : 283-291 (1989). [PMID: 2496760]
  4. Shibata, D., Steczko, J., Dixon, F.E., Hermodson, M., Yasdanparast, R. and Axelrod, B.
    Primary structure of soybean lipoxygenase-1.
    J. Biol. Chem. 262 : 10080-10085 (1987). [PMID: 3112136]

[EC created 1984]