IntEnz - EC 1.13.11.27

EC 1 - Oxidoreductases

EC 1.13 - Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O₂

EC 1.13.11 - With incorporation of two atoms of oxygen

EC 1.13.11.27 - 4-hydroxyphenylpyruvate dioxygenase

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IntEnz Enzyme Nomenclature
EC 1.13.11.27

Names

Accepted name:

4-hydroxyphenylpyruvate dioxygenase

Other names:

4-hydroxyphenylpyruvic acid dioxygenase
p-hydroxyphenylpyruvate dioxygenase
p-hydroxyphenylpyruvate hydroxylase
p-hydroxyphenylpyruvate oxidase
p-hydroxyphenylpyruvic acid hydroxylase
p-hydroxyphenylpyruvic hydroxylase
p-hydroxyphenylpyruvic oxidase
4-hydroxyphenylpyruvate hydroxylase

Systematic name:

4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)

Reaction

16189 [IUBMB]

3-(4-hydroxyphenyl)pyruvate

3-(4-hydroxyphenyl)pyruvate

Name origin: UniProt - CHECKED (C)

CHEBI:36242

Formula: C9H7O4
Charge: -1

ChEBI compound status: CHECKED (C)

+

O₂

O2

Name origin: UniProt - CHECKED (C)

CHEBI:15379

Formula: O2
Charge: 0

ChEBI compound status: CHECKED (C)

=

CO₂

CO2

Name origin: UniProt - CHECKED (C)

CHEBI:16526

Formula: CO2
Charge: 0

ChEBI compound status: CHECKED (C)

+

homogentisate

homogentisate

Name origin: UniProt - CHECKED (C)

CHEBI:16169

Formula: C8H7O4
Charge: -1

ChEBI compound status: CHECKED (C)

Cofactor

Fe cation

Comments:

The Pseudomonas enzyme contains one Fe³⁺ per mole of enzyme; the enzymes from other sources may contain essential iron or copper.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0003868

CAS Registry Number: 9029-72-5

UniProtKB/Swiss-Prot: (30) [show] [UniProt]

References

Lindstedt, S. and Rundgren, M.

Blue color, metal content, and substrate binding in 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P. J. 874.

J. Biol. Chem. 257: 11922-11931 (1982). [PMID: 7118918]
Roche, P.A., Moorehead, T.J. and Hamilton, G.A.

Purification and properties of hog liver 4-hydroxyphenylpyruvate dioxygenase.

Arch. Biochem. Biophys. 216: 62-73 (1982). [PMID: 7103516]

[EC 1.13.11.27 created 1961 as EC 1.99.1.14, transferred 1965 to EC 1.14.2.2, transferred 1972 to EC 1.13.11.27]