EC - 4-hydroxyphenylpyruvate dioxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
4-hydroxyphenylpyruvate dioxygenase
Other names:
4-hydroxyphenylpyruvic acid dioxygenase
p-hydroxyphenylpyruvate dioxygenase
p-hydroxyphenylpyruvate hydroxylase
p-hydroxyphenylpyruvate oxidase
p-hydroxyphenylpyruvic acid hydroxylase
p-hydroxyphenylpyruvic hydroxylase
p-hydroxyphenylpyruvic oxidase
4-hydroxyphenylpyruvate hydroxylase
Systematic name:
4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)




The Pseudomonas enzyme contains one Fe3+ per mole of enzyme; the enzymes from other sources may contain essential iron or copper.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003868
CAS Registry Number: 9029-72-5
UniProtKB/Swiss-Prot: (32) [show] [UniProt]


  1. Lindstedt, S. and Rundgren, M.
    Blue color, metal content, and substrate binding in 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P. J. 874.
    J. Biol. Chem. 257 : 11922-11931 (1982). [PMID: 7118918]
  2. Roche, P.A., Moorehead, T.J. and Hamilton, G.A.
    Purification and properties of hog liver 4-hydroxyphenylpyruvate dioxygenase.
    Arch. Biochem. Biophys. 216 : 62-73 (1982). [PMID: 7103516]

[EC created 1961 as EC, transferred 1965 to EC, transferred 1972 to EC]