IntEnz - EC 1.13.11.25

EC 1 - Oxidoreductases

EC 1.13 - Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O₂

EC 1.13.11 - With incorporation of two atoms of oxygen

EC 1.13.11.25 - 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase

IntEnz view ENZYME view

XML

IntEnz Enzyme Nomenclature
EC 1.13.11.25

Names

Accepted name:

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase

Other names:

3-alkylcatechol 2,3-dioxygenase
steroid 4,5-dioxygenase
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)

Systematic name:

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (ring-opening)

Reaction

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate

Cofactor

Fe cation

Comments:

Requires Fe2+. Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0047071

CAS Registry Number: 37256-63-6

UniProtKB/Swiss-Prot:

P9WNW6

HSAC_MYCTO

P9WNW7

HSAC_MYCTU

Q9KWQ5

HSAC_RHOJR

References

Gibson, D.T., Wang, K.C., Sih, C.J. and Whitlock, J.H.

Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms.

J. Biol. Chem. 241 : 551-559 (1966). [PMID: 5908121]

[EC 1.13.11.25 created 1972]