EC 1 - Oxidoreductases
EC 1.13 - Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2
EC 1.13.11 - With incorporation of two atoms of oxygen
EC 1.13.11.25 - 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.13.11.25
Names
Accepted name:
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
Other
names:
3-alkylcatechol 2,3-dioxygenase
steroid 4,5-dioxygenase
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)
steroid 4,5-dioxygenase
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)
Systematic name:
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (ring-opening)
Reaction
- 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate
Cofactor
Comments:
Requires Fe2+. Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.
Links to other databases
Gene Ontology:
GO:0047071
CAS Registry Number:
37256-63-6
UniProtKB/Swiss-Prot:
References
-
Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms.J. Biol. Chem. 241 : 551-559 (1966). [PMID: 5908121]
[EC 1.13.11.25 created 1972]