IntEnz

EC 1.13.11.25 - 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase

IntEnz Enzyme Nomenclature
EC 1.13.11.25

Names

Reaction

• 21352 [IUBMB]
  3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione

  3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione

  Name origin: UniProt - CHECKED (C)

  CHEBI:15896

  Formula: C19H24O4
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  O₂

  O2

  Name origin: UniProt - CHECKED (C)

  CHEBI:15379

  Formula: O2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate

  (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate

  Name origin: UniProt - CHECKED (C)

  CHEBI:63690

  Formula: C19H23O6
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Cofactor

• Fe cation

Comments:

Requires Fe2+. Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.

Links to other databases

References

1. Gibson, D.T., Wang, K.C., Sih, C.J. and Whitlock, J.H.
   Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms.
   J. Biol. Chem. 241 : 551-559 (1966). [PMID: 5908121]

[EC 1.13.11.25 created 1972]