EC 1.13.11.19 - Cysteamine dioxygenase

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IntEnz Enzyme Nomenclature
EC 1.13.11.19

Names

Accepted name:
cysteamine dioxygenase
Other names:
cysteamine oxygenase
persulfurase
cysteamine:oxygen oxidoreductase
Systematic name:
2-aminoethanethiol:oxygen oxidoreductase

Reaction

Cofactor

Comments:

A non-heme iron protein that is involved in the biosynthesis of taurine. Requires catalytic amounts of a cofactor-like compound, such as sulfur, sufide, selenium or methylene blue for maximal activity. 3-Aminopropanethiol (homocysteamine) and 2-mercaptoethanol can also act as substrates, but glutathione, cysteine, and cysteine ethyl- and methyl esters are not good substrates [1,3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047800
CAS Registry Number: 9033-41-4
UniProtKB/Swiss-Prot:

References

  1. Cavallini, D., de Marco, C., Scandurra, R., Dupré, S. and Graziani, M.T.
    The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme.
    J. Biol. Chem. 241: 3189-3196 (1966). [PMID: 5912113]
  2. Wood, J.L. and Cavallini, D.
    Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor.
    Arch. Biochem. Biophys. 119: 368-372 (1967). [PMID: 6052430]
  3. Cavallini, D., Federici, G., Ricci, G., Dupré, S. and Antonucci, A.
    The specificity of cysteamine oxygenase.
    FEBS Lett. 56: 348-351 (1975). [PMID: 1157952]
  4. Richerson, R.B. and Ziegler, D.M.
    Cysteamine dioxygenase.
    Meth. Enzymol. 143: 410-415 (1987). [PMID: 3657558]

[EC 1.13.11.19 created 1972, modified 2006]