EC - Cysteamine dioxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
cysteamine dioxygenase
Other names:
cysteamine oxygenase
cysteamine:oxygen oxidoreductase
Systematic name:
2-aminoethanethiol:oxygen oxidoreductase




A non-heme iron protein that is involved in the biosynthesis of taurine. Requires catalytic amounts of a cofactor-like compound, such as sulfur, sufide, selenium or methylene blue for maximal activity. 3-Aminopropanethiol (homocysteamine) and 2-mercaptoethanol can also act as substrates, but glutathione, cysteine, and cysteine ethyl- and methyl esters are not good substrates [1,3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047800
CAS Registry Number: 9033-41-4


  1. Cavallini, D., de Marco, C., Scandurra, R., Dupré, S. and Graziani, M.T.
    The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme.
    J. Biol. Chem. 241: 3189-3196 (1966). [PMID: 5912113]
  2. Wood, J.L. and Cavallini, D.
    Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor.
    Arch. Biochem. Biophys. 119: 368-372 (1967). [PMID: 6052430]
  3. Cavallini, D., Federici, G., Ricci, G., Dupré, S. and Antonucci, A.
    The specificity of cysteamine oxygenase.
    FEBS Lett. 56: 348-351 (1975). [PMID: 1157952]
  4. Richerson, R.B. and Ziegler, D.M.
    Cysteamine dioxygenase.
    Meth. Enzymol. 143: 410-415 (1987). [PMID: 3657558]

[EC created 1972, modified 2006]