EC - Persulfide dioxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
persulfide dioxygenase
Other names:
sulfur oxygenase [incorrect]
sulfur:oxygen oxidoreductase [incorrect]
sulfur dioxygenase [incorrect]
Systematic name:
S-sulfanylglutathione:oxygen oxidoreductase




An iron protein. Perthiols, formed spontaneously by interactions between thiols and elemental sulfur or sulfide, are the only acceptable substrate to the enzyme. The sulfite that is formed by the enzyme can be further converted into sulfate, thiosulfate or S-sulfoglutathione (GSSO3-) non-enzymically [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050313
CAS Registry Number: 37256-58-9


  1. Suzuki, I. and Silver, M.
    The initial product and properties of the sulfur-oxidizing enzyme of thiobacilli.
    Biochim. Biophys. Acta 122: 22-33 (1966). [PMID: 5968172]
  2. Rohwerder, T. and Sand, W.
    The sulfane sulfur of persulfides is the actual substrate of the sulfur-oxidizing enzymes from Acidithiobacillus and Acidiphilium spp.
    Microbiology 149: 1699-1710 (2003). [PMID: 12855721]
  3. Liu, H., Xin, Y., Xun, L.
    Distribution, diversity, and activities of sulfur dioxygenases in heterotrophic bacteria.
    Appl. Environ. Microbiol. 80: 1799-1806 (2014). [PMID: 24389926]
  4. Holdorf, M. M., Owen, H. A., Lieber, S. R., Yuan, L., Adams, N., Dabney-Smith, C., Makaroff, C. A.
    Arabidopsis ETHE1 encodes a sulfur dioxygenase that is essential for embryo and endosperm development.
    Plant Physiol. 160: 226-236 (2012). [PMID: 22786886]
  5. Pettinati, I., Brem, J., McDonough, M. A., Schofield, C. J.
    Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.
    Hum. Mol. Genet. 24: 2458-2469 (2015). [PMID: 25596185]

[EC created 1972, modified 2015]