EC - 3,4-dihydroxyphenylacetate 2,3-dioxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
3,4-dihydroxyphenylacetate 2,3-dioxygenase
Other names:
3,4-dihydroxyphenylacetic acid 2,3-dioxygenase
HPC dioxygenase
homoprotocatechuate 2,3-dioxygenase
3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)
Systematic name:
3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (ring-opening)




An iron protein.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008687
CAS Registry Number: 37256-56-7


  1. Adachi, K., Takeda, Y., Senoh, S. and Kita, H.
    Metabolism of p-hydroxyphenylacetic acid in Pseudomonas ovalis.
    Biochim. Biophys. Acta 93 : 483-493 (1964).
  2. Barbour, M.G. and Bayly, R.C.
    Control of meta-cleavage degradation of 4-hydroxyphenylacetate in Pseudomonas putida.
    J. Bacteriol. 147 : 844-850 (1981). [PMID: 6895079]
  3. Krishnan Kutty, R., Devi, N.A., Veeraswamy, M., Ramesh, S. and Subba Rao, P.V.
    Degradation of (+/-)-synephrine by Arthrobacter synephrinum. Oxidation of 3,4-dihydroxyphenylacetate to 2-hydroxy-5-carboxymethyl-muconate semialdehyde.
    Biochem. J. 167 : 163-170 (1977). [PMID: 588248]

[EC created 1972]