EC - Linoleate 13S-lipoxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
linoleate 13S-lipoxygenase
Other names:
carotene oxidase
fat oxidase
lionoleate:O2 13-oxidoreductase
Systematic name:
linoleate:oxygen 13-oxidoreductase




Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and α-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C13 position with (S)-configuration. This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. EC, linoleate 9S-lipoxygenase, catalyses a similar reaction at the second available position of these fatty acids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00077
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016165
CAS Registry Number: 9029-60-1
UniProtKB/Swiss-Prot: (26) [show] [UniProt]


  1. Christopher, J., Pistorius, E. and Axelrod, B.
    Isolation of an enzyme of soybean lipoxidase.
    Biochim. Biophys. Acta 198 : 12-19 (1970). [PMID: 5461103]
  2. Theorell, H., Holman, R.T. and Åkesson, Å.
    Crystalline lipoxidase.
    Acta Chem. Scand. 1 : 571-576 (1947). [PMID: 18907700]
  3. Zimmerman, D.C.
    Specificity of flaxseed lipoxidase.
    Lipids 5 : 392-397 (1970). [PMID: 5447012]
  4. Royo, J., Vancanneyt, G., Perez, A. G., Sanz, C., Stormann, K., Rosahl, S., Sanchez-Serrano, J. J.
    Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns.
    J. Biol. Chem. 271 : 21012-21019 (1996). [PMID: 8702864]
  5. Bachmann, A., Hause, B., Maucher, H., Garbe, E., Voros, K., Weichert, H., Wasternack, C., Feussner, I.
    Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts.
    Biol. Chem. 383 : 1645-1657 (2002). [PMID: 12452441]

[EC created 1961 as EC, transferred 1965 to EC, transferred 1972 to EC, modified 2011, modified 2012]