EC - Methanosarcina-phenazine hydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
Methanosarcina-phenazine hydrogenase
Other names:
methanophenazine hydrogenase
methylviologen-reducing hydrogenase
Systematic name:
hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase




Contains nickel, iron-sulfur clusters and cytochrome b. The enzyme from some sources contains selenocysteine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0051911
UniProtKB/Swiss-Prot: (15) [show] [UniProt]


  1. Abken, H.J., Tietze, M., Brodersen, J., Baumer, S., Beifuss, U. and Deppenmeier, U.
    Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Gö1.
    J. Bacteriol. 180: 2027-2032 (1998). [PMID: 9555882]
  2. Deppenmeier, U., Lienard, T. and Gottschalk, G.
    Novel reactions involved in energy conservation by methanogenic archaea.
    FEBS Lett. 457: 291-297 (1999). [PMID: 10471795]
  3. Beifuss, U., Tietze, M., Baumer, S. and Deppenmeier, U.
    Methanophenazine: structure, total synthesis, and function of a new cofactor from methanogenic Archaea.
    Angew. Chem. Int. Ed. Engl. 39: 2470-2472 (2000). [PMID: 10941105]

[EC created 2002]