EC - Cytochrome-c3 hydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
cytochrome-c3 hydrogenase
Other names:
H2:ferricytochrome c3 oxidoreductase
cytochrome c3 reductase
cytochrome hydrogenase
hydrogenase [ambiguous]
Systematic name:
hydrogen:ferricytochrome-c3 oxidoreductase




An iron-sulfur protein. Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases). Methylene blue and other acceptors can also be reduced.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047806
CAS Registry Number: 9027-05-8
UniProtKB/Swiss-Prot: (12) [show] [UniProt]


  1. DerVartanian, D.V. and Le Gall, J.
    A monomolecular electron transfer chain: structure and function of cytochrome c3.
    Biochim. Biophys. Acta 346 : 79-99 (1974). [PMID: 4364940]
  2. Higuchi, Y., Yasuoka, N., Kakudo, M., Katsube, Y., Yagi, T. and Inokuchi, H.
    Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki F.
    J. Biol. Chem. 262 : 2823-2825 (1987). [PMID: 3546297]
  3. Rilkis, E. and Rittenberg, D.
    Some observations on the enzyme, hydrogenase.
    J. Biol. Chem. 236 : 2526-2529 (1961). [PMID: 13741672]
  4. Sadana, J.C. and Morey, A.V.
    Purification and properties of the hydrogenase of Desulfovibrio desulfuricans.
    Biochim. Biophys. Acta 50 : 153-163 (1961). [PMID: 13745271]
  5. Volbeda, A., Charon, M.H., Piras, C., Hatchikian, E.C., Frey, M. and Fontecillacamps, J.C.
    Crystal-structure of the nickel-iron hydrogenase from Desulfovibrio gigas.
    Nature 373 : 580-587 (1995). [PMID: 7854413]
  6. Garcin, E., Vernede, X., Hatchikian, E.C., Volbeda, A., Frey, M. and Fontecilla-Camps, J.C.
    The crystal structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center.
    Structure Fold. Des. 7 : 557-566 (1999). [PMID: 10378275]

[EC created 1972, modified 2002]