EC 1.11.1.9 - Glutathione peroxidase
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IntEnz Enzyme Nomenclature
EC 1.11.1.9
Names
Accepted name:
glutathione peroxidase
Other
names:
GSH peroxidase
reduced glutathione peroxidase
selenium-glutathione peroxidase
reduced glutathione peroxidase
selenium-glutathione peroxidase
Systematic name:
glutathione:hydrogen-peroxide oxidoreductase
Reaction
- 2 glutathione + H2O2 = glutathione disulfide + 2 H2O
Cofactor
Comments:
A protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 lipoxygenase on phospholipids, can act as acceptor, but more slowly than H2O2 (cf. EC 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase).
Links to other databases
Protein domains and families:
PROSITE:PDOC00396
Gene Ontology:
GO:0004602
CAS Registry Number:
9013-66-5
References
-
Purification and characterization of selenium-glutathione peroxidase from hamster liver.Arch. Biochem. Biophys. 226 : 448-457 (1983). [PMID: 6227287]
-
Non-reactivity of the selenoenzyme glutathione peroxidase with enzymatically hydroperoxidized phospholipids.Eur. J. Biochem. 135 : 549-552 (1983). [PMID: 6413205]
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Purification and properties of rat liver glutathione peroxidase.Biochim. Biophys. Acta 358 : 251-261 (1974).
[EC 1.11.1.9 created 1965, modified 1989]