EC 1.11.1.9 - Glutathione peroxidase

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IntEnz Enzyme Nomenclature
EC 1.11.1.9

Names

Accepted name:
glutathione peroxidase
Other names:
GSH peroxidase
reduced glutathione peroxidase
selenium-glutathione peroxidase
Systematic name:
glutathione:hydrogen-peroxide oxidoreductase

Reaction

Cofactor

Comments:

A protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 lipoxygenase on phospholipids, can act as acceptor, but more slowly than H2O2 (cf. EC 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00396
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004602
CAS Registry Number: 9013-66-5
UniProtKB/Swiss-Prot: (78) [show] [UniProt]

References

  1. Chaudiere, J. and Tappel, A.L.
    Purification and characterization of selenium-glutathione peroxidase from hamster liver.
    Arch. Biochem. Biophys. 226 : 448-457 (1983). [PMID: 6227287]
  2. Grossmann, A. and Wendel, A.
    Non-reactivity of the selenoenzyme glutathione peroxidase with enzymatically hydroperoxidized phospholipids.
    Eur. J. Biochem. 135 : 549-552 (1983). [PMID: 6413205]
  3. Nakamura, W., Hosoda, S. and Hayashi, K.
    Purification and properties of rat liver glutathione peroxidase.
    Biochim. Biophys. Acta 358 : 251-261 (1974).

[EC 1.11.1.9 created 1965, modified 1989]