IntEnz

EC 1.11.1.8 - Iodide peroxidase

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IntEnz Enzyme Nomenclature
EC 1.11.1.8

Names

Accepted name:

iodide peroxidase

Other names:

iodide peroxidase-tyrosine iodinase
iodinase
iodoperoxidase (heme type)
iodotyrosine deiodase
iodotyrosine deiodinase
monoiodotyrosine deiodinase
thyroid peroxidase
thyroperoxidase
tyrosine iodinase
TPO

Systematic name:

iodide:hydrogen-peroxide oxidoreductase

Reactions

23336 [IUBMB]

2

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

H₂O₂

H2O2

Name origin: UniProt - CHECKED (C)

CHEBI:16240

Formula: H2O2
Charge: 0

ChEBI compound status: CHECKED (C)

+
2

iodide

iodide

Name origin: UniProt - CHECKED (C)

CHEBI:16382

Formula: I
Charge: -1

ChEBI compound status: CHECKED (C)

=

diiodine

diiodine

Name origin: UniProt - CHECKED (C)

CHEBI:17606

Formula: I2
Charge: 0

ChEBI compound status: CHECKED (C)

+
2

H₂O

H2O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

48956 [IUBMB]

[thyroglobulin]-L-tyrosine

GENERIC:12274

Is ROOT: no
ROOT compound: GENERIC:12273

Number of residues: 1

L-tyrosine residue

Name origin: UniProt - CHECKED (C)

CHEBI:46858

Formula: C9H9NO2
Charge: 0

Position: undefined

ChEBI compound status: CHECKED (C)

H⁺

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

H₂O₂

Name origin: UniProt - CHECKED (C)

CHEBI:16240

Formula: H2O2
Charge: 0

ChEBI compound status: CHECKED (C)

iodide

Name origin: UniProt - CHECKED (C)

CHEBI:16382

Formula: I
Charge: -1

ChEBI compound status: CHECKED (C)

[thyroglobulin]-3-iodo-L-tyrosine

GENERIC:12275

Is ROOT: no
ROOT compound: GENERIC:12273

Number of residues: 1

3-iodo-L-tyrosine residue

Name origin: UniProt - CHECKED (C)

CHEBI:90870

Formula: C9H8INO2
Charge: 0

Position: undefined

ChEBI compound status: CHECKED (C)

H₂O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

48960 [IUBMB]

[thyroglobulin]-3-iodo-L-tyrosine

GENERIC:12275

Is ROOT: no
ROOT compound: GENERIC:12273

Number of residues: 1

3-iodo-L-tyrosine residue

Name origin: UniProt - CHECKED (C)

CHEBI:90870

Formula: C9H8INO2
Charge: 0

Position: undefined

ChEBI compound status: CHECKED (C)

H⁺

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

H₂O₂

Name origin: UniProt - CHECKED (C)

CHEBI:16240

Formula: H2O2
Charge: 0

ChEBI compound status: CHECKED (C)

iodide

Name origin: UniProt - CHECKED (C)

CHEBI:16382

Formula: I
Charge: -1

ChEBI compound status: CHECKED (C)

[thyroglobulin]-3,5-diiodo-L-tyrosine

GENERIC:12276

Is ROOT: no
ROOT compound: GENERIC:12273

Number of residues: 1

3,5-diiodo-L-tyrosine residue

Name origin: UniProt - CHECKED (C)

CHEBI:90871

Formula: C9H7I2NO2
Charge: 0

Position: undefined

ChEBI compound status: CHECKED (C)

H₂O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

48964 [IUBMB]

[thyroglobulin]-3,5-diiodo-L-tyrosine

GENERIC:12276

Is ROOT: no
ROOT compound: GENERIC:12273

Number of residues: 1

3,5-diiodo-L-tyrosine residue

Name origin: UniProt - CHECKED (C)

CHEBI:90871

Formula: C9H7I2NO2
Charge: 0

Position: undefined

ChEBI compound status: CHECKED (C)

H₂O₂

Name origin: UniProt - CHECKED (C)

CHEBI:16240

Formula: H2O2
Charge: 0

ChEBI compound status: CHECKED (C)

[thyroglobulin]-dehydroalanine

GENERIC:12278

Is ROOT: no
ROOT compound: GENERIC:12273

Number of residues: 1

dehydroalanine residue

Name origin: UniProt - CHECKED (C)

CHEBI:90873

Formula: C3H3NO
Charge: 0

Position: undefined

ChEBI compound status: CHECKED (C)

[thyroglobulin]-L-thyroxine

GENERIC:12277

Is ROOT: no
ROOT compound: GENERIC:12273

Number of residues: 1

L-thyroxine residue

Name origin: UniProt - CHECKED (C)

CHEBI:90872

Formula: C15H9I4NO3
Charge: 0

Position: undefined

ChEBI compound status: CHECKED (C)

H₂O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

48968 [IUBMB]

[thyroglobulin]-3,5-diiodo-L-tyrosine

GENERIC:12276

Is ROOT: no
ROOT compound: GENERIC:12273

Number of residues: 1

3,5-diiodo-L-tyrosine residue

Name origin: UniProt - CHECKED (C)

CHEBI:90871

Formula: C9H7I2NO2
Charge: 0

Position: undefined

ChEBI compound status: CHECKED (C)

[thyroglobulin]-3-iodo-L-tyrosine

GENERIC:12275

Is ROOT: no
ROOT compound: GENERIC:12273

Number of residues: 1

3-iodo-L-tyrosine residue

Name origin: UniProt - CHECKED (C)

CHEBI:90870

Formula: C9H8INO2
Charge: 0

Position: undefined

ChEBI compound status: CHECKED (C)

H₂O₂

Name origin: UniProt - CHECKED (C)

CHEBI:16240

Formula: H2O2
Charge: 0

ChEBI compound status: CHECKED (C)

[thyroglobulin]-3,3',5-triiodo-L-thyronine

GENERIC:12279

Is ROOT: no
ROOT compound: GENERIC:12273

Number of residues: 1

3,3',5-triiodo-L-thyronine residue

Name origin: UniProt - CHECKED (C)

CHEBI:90874

Formula: C15H10I3NO3
Charge: 0

Position: undefined

ChEBI compound status: CHECKED (C)

[thyroglobulin]-dehydroalanine

GENERIC:12278

Is ROOT: no
ROOT compound: GENERIC:12273

Number of residues: 1

dehydroalanine residue

Name origin: UniProt - CHECKED (C)

CHEBI:90873

Formula: C3H3NO
Charge: 0

Position: undefined

ChEBI compound status: CHECKED (C)

H₂O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

Cofactor

heme

Comments:

Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Protein domains and families: PROSITE:PDOC00394

Structural data: CSA , EC2PDB

Gene Ontology: GO:0004447

CAS Registry Number: 9031-28-1

UniProtKB/Swiss-Prot:

Q8HYB7

PERT_CANLF

P07202

PERT_HUMAN

P35419

PERT_MOUSE

P09933

PERT_PIG

P14650

PERT_RAT

References

Cunningham, B. A., Kirkwood, S.

Enzyme systems concerned with the synthesis of monoiodotyrosine. III. Ion requirements of the soluble system.

J. Biol. Chem. 236: 485-489 (1961). [PMID: 13718859]
Hosoya, T., Kondo, Y., Ui, N.

Peroxidase activity in thyroid gland and partial purification of the enzyme.

J. Biochem. 52: 180-189 (1962). [PMID: 13964156]
Coval, M. L., Taurog, A.

Purification and iodinating activity of hog thyroid peroxidase.

J. Biol. Chem. 242: 5510-5523 (1967). [PMID: 12325367]
Gavaret, J. M., Cahnmann, H. J., Nunez, J.

Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction.

J. Biol. Chem. 256: 9167-9173 (1981). [PMID: 7021557]
Ohtaki, S., Nakagawa, H., Nakamura, M., Yamazaki, I.

One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase.

J. Biol. Chem. 257: 13398-13403 (1982). [PMID: 7142155]
Magnusson, R. P., Taurog, A., Dorris, M. L.

Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase.

J. Biol. Chem. 259: 197-205 (1984). [PMID: 6706930]
Virion, A., Courtin, F., Deme, D., Michot, J. L., Kaniewski, J., Pommier, J.

Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions.

Arch. Biochem. Biophys. 242: 41-47 (1985). [PMID: 2996435]
Rawitch, A. B., Pollock, G., Yang, S. X., Taurog, A.

Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase.

Arch. Biochem. Biophys. 297: 321-327 (1992). [PMID: 1497352]
Sun, W., Dunford, H. B.

Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine.

Biochemistry 32: 1324-1331 (1993). [PMID: 8448141]
Taurog, A., Dorris, M. L., Doerge, D. R.

Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase.

Arch. Biochem. Biophys. 330: 24-32 (1996). [PMID: 8651700]
Ruf, J., Carayon, P.

Structural and functional aspects of thyroid peroxidase.

Arch. Biochem. Biophys. 445: 269-277 (2006). [PMID: 16098474]

[EC 1.11.1.8 created 1961, modified 2012]

EC 1 - Oxidoreductases

EC 1.11 - Acting on a peroxide as acceptor

EC 1.11.1 - Peroxidases

EC 1.11.1.8 - Iodide peroxidase

Names

Reactions

Cofactor

Comments:

Links to other databases

References