EC - Bromide peroxidase

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IntEnz Enzyme Nomenclature


Accepted name:
bromide peroxidase
Other names:
haloperoxidase [ambiguous]
eosinophil peroxidase
Systematic name:
bromide:hydrogen-peroxide oxidoreductase



Bromoperoxidases of red and brown marine algae (Rhodophyta and Phaeophyta) contain vanadate. They catalyse the bromination of a range of organic molecules such as sesquiterpenes, forming stable C-Br bonds. Bromoperoxidases also oxidize iodides.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. De Boer, E., Tromp, M.G.M., Plat, H., Krenn, G.E. and Wever, R.
    Vanadium(V) as an essential element for haloperoxidase activity in marine brown-algae - purification and characterization of a vanadium(V)-containing bromoperoxidase from Laminaria saccharina.
    Biochim. Biophys. Acta 872: 104-115 (1986).
  2. Tromp, M. G., Olafsson, G., Krenn, B. E., Wever, R.
    Some structural aspects of vanadium bromoperoxidase from Ascophyllum nodosum.
    Biochim. Biophys. Acta 1040: 192-198 (1990). [PMID: 2400770]
  3. Isupov, M. N., Dalby, A. R., Brindley, A. A., Izumi, Y., Tanabe, T., Murshudov, G. N., Littlechild, J. A.
    Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis.
    J. Mol. Biol. 299: 1035-1049 (2000). [PMID: 10843856]
  4. Carter-Franklin, J. N., Butler, A.
    Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products.
    J. Am. Chem. Soc. 126: 15060-15066 (2004). [PMID: 15548002]
  5. Ohshiro, T., Littlechild, J., Garcia-Rodriguez, E., Isupov, M. N., Iida, Y., Kobayashi, T., Izumi, Y.
    Modification of halogen specificity of a vanadium-dependent bromoperoxidase.
    Protein Sci. 13: 1566-1571 (2004). [PMID: 15133166]

[EC created 2010]