EC 1.11.1.16 - Versatile peroxidase

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IntEnz Enzyme Nomenclature
EC 1.11.1.16

Names

Accepted name:
versatile peroxidase
Other names:
VP
hybrid peroxidase
polyvalent peroxidase
reactive-black-5:hydrogen-peroxide oxidoreductase
Systematic name:
1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol:hydrogen-peroxide oxidoreductase

Reactions

Cofactor

Comments:

A hemoprotein. This ligninolytic peroxidase combines the substrate-specificity characteristics of the two other ligninolytic peroxidases, EC 1.11.1.13, manganese peroxidase and EC 1.11.1.14, lignin peroxidase. Unlike these two enzymes, it is also able to oxidize phenols, hydroquinones and both low- and high-redox-potential dyes, due to a hybrid molecular architecture that involves multiple binding sites for substrates [2,4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00394
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052750
UniProtKB/Swiss-Prot:

References

  1. Martínez, M.J., Ruiz-Dueñas, F. J., Guillén, F. and Martínez, A.T.
    Purification and catalytic properties of two manganese peroxidase isoenzymes from Pleurotus eryngii.
    Eur. J. Biochem. 237: 424-432 (1996). [PMID: 8647081]
  2. Heinfling, A., Ruiz-Dueñas, F.J., Martínez, M.J., Bergbauer, M., Szewzyk, U. and Martínez, A.T.
    A study on reducing substrates of manganese-oxidizing peroxidases from Pleurotus eryngii and Bjerkandera adusta.
    FEBS Lett. 428: 141-146 (1998). [PMID: 9654123]
  3. Ruiz-Dueñas, F.J., Martínez, M.J. and Martínez, A.T.
    Molecular characterization of a novel peroxidase isolated from the ligninolytic fungus Pleurotus eryngii.
    Mol. Microbiol. 31: 223-235 (1999). [PMID: 9987124]
  4. Camarero, S., Sarkar, S., Ruiz-Dueñas, F.J., Martínez, M.J. and Martínez, A.T.
    Description of a versatile peroxidase involved in the natural degradation of lignin that has both manganese peroxidase and lignin peroxidase substrate interaction sites.
    J. Biol. Chem. 274: 10324-10330 (1999). [PMID: 10187820]
  5. Ruiz-Dueñas, F.J., Martínez, M.J. and Martínez, A.T.
    Heterologous expression of Pleurotus eryngii peroxidase confirms its ability to oxidize Mn2+ and different aromatic substrates.
    Appl. Environ. Microbiol. 65: 4705-4707 (1999). [PMID: 10508113]
  6. Camarero, S., Ruiz-Dueñas, F.J., Sarkar, S., Martínez, M.J. and Martínez, A.T.
    The cloning of a new peroxidase found in lignocellulose cultures of Pleurotus eryngii and sequence comparison with other fungal peroxidases.
    FEMS Microbiol. Lett. 191: 37-43 (2000). [PMID: 11004397]
  7. Ruiz-Dueñas, F.J., Camarero, S., Pérez-Boada, M., Martínez, M.J. and Martínez, A.T.
    A new versatile peroxidase from Pleurotus.
    Biochem. Soc. Trans. 29: 116-122 (2001). [PMID: 11356138]
  8. Banci, L., Camarero, S., Martínez, A.T., Martínez, M.J., Pérez-Boada, M., Pierattelli, R. and Ruiz-Dueñas, F.J.
    NMR study of manganese(II) binding by a new versatile peroxidase from the white-rot fungus Pleurotus eryngii.
    J. Biol. Inorg. Chem. 8: 751-760 (2003). [PMID: 12884090]
  9. Pérez-Boada, M., Ruiz-Dueñas, F.J., Pogni, R., Basosi, R., Choinowski, T., Martínez, M.J., Piontek, K. and Martínez, A. T.
    Versatile peroxidase oxidation of high redox potential aromatic compounds: site-directed mutagenesis, spectroscopic and crystallographic investigation of three long-range electron transfer pathways.
    J. Mol. Biol. 354: 385-402 (2005). [PMID: 16246366]
  10. Caramelo, L., Martínez, M.J. and Martínez, A.T.
    A search for ligninolytic peroxidases in the fungus Pleurotus eryngii involving α-keto-γ-thiomethylbutyric acid and lignin model dimers
    Appl. Environ. Microbiol. 65: 916-922 (1999). [PMID: 10049842]

[EC 1.11.1.16 created 2006, modified 2016]