EC 1.11.1.13 - Manganese peroxidase

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IntEnz Enzyme Nomenclature
EC 1.11.1.13

Names

Accepted name:
manganese peroxidase
Other names:
Mn-dependent (NADH-oxidizing) peroxidase
peroxidase-M2
Mn-dependent peroxidase
Systematic name:
Mn(II):hydrogen-peroxide oxidoreductase

Reaction

Cofactor

Comments:

A hemoprotein. The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin. The enzyme oxidizes a bound Mn2+ ion to Mn3+ in the presence of hydrogen peroxide. The product, Mn3+, is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn2+ and insoluble Mn4+ [4]. The complexed Mn3+ ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates [1]. It is inactive with veratryl alcohol or nonphenolic substrates.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00394
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016689
CAS Registry Number: 114995-15-2
UniProtKB/Swiss-Prot:

References

  1. Glenn, J.K., Akileswaran, L. and Gold, M.H.
    Mn(II) oxidation is the principal function of the extracellular Mn-peroxidase from Phanerochaete chrysosporium.
    Arch. Biochem. Biophys. 251: 688-696 (1986).
  2. Paszczynski, A., Huynh, V.-B. and Crawford, R.
    Comparison of ligninase-I and peroxidase-M2 from the white-rot fungus Phanerochaete chrysosporium.
    Arch. Biochem. Biophys. 244: 750-765 (1986). [PMID: 3080953]
  3. Wariishi, H., Akileswaran, L. and Gold, M.H.
    Manganese peroxidase from the basidiomycete Phanerochaete chrysosporium: spectral characterization of the oxidized states and the catalytic cycle.
    Biochemistry 27: 5365-5370 (1988).
  4. Kuan, I. C., Tien, M.
    Stimulation of Mn peroxidase activity: a possible role for oxalate in lignin biodegradation.
    Proc. Natl. Acad. Sci. U.S.A. 90: 1242-1246 (1993). [PMID: 8433984]

[EC 1.11.1.13 created 1992]