EC 1.11.1.11 - L-ascorbate peroxidase

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IntEnz Enzyme Nomenclature
EC 1.11.1.11

Names

Accepted name:
L-ascorbate peroxidase
Other names:
L-ascorbic acid peroxidase
L-ascorbic acid-specific peroxidase
ascorbate peroxidase
ascorbic acid peroxidase
Systematic name:
L-ascorbate:hydrogen-peroxide oxidoreductase

Reaction

Cofactor

Comments:

A heme protein. Oxidizes ascorbate and low molecular weight aromatic substrates. The monodehydroascorbate radical produced is either directly reduced back to ascorbate by EC 1.6.5.4 [monodehydroascorbate reductase (NADH)] or undergoes non-enzymatic disproportionation to ascorbate and dehydroascorbate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00394
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016688
CAS Registry Number: 72906-87-7
UniProtKB/Swiss-Prot: (20) [show] [UniProt]

References

  1. Shigeoka, S., Nakano, Y. and Kitaoka, S.
    Purification and some properties of L-ascorbic-acid-specific peroxidase in Euglena gracilis. Z.
    Arch. Biochem. Biophys. 201: 121-127 (1980). [PMID: 6772104]
  2. Shigeoka, S., Nakano, Y. and Kitaoka, S.
    Metabolism of hydrogen peroxide in Euglena gracilis Z by L-ascorbic acid peroxidase.
    Biochem. J. 186: 377-380 (1980). [PMID: 6768357]
  3. Nakano, Y and Asada, K.
    Purification of ascorbate peroxidase in spinach chloroplasts; its inactivation in ascorbate-depleted medium and reactivation by monodehydroascorbate radical.
    Plant Cell Physiol. 28: 131-140 (1987).
  4. Patterson, W. R., Poulos, T. L.
    Crystal structure of recombinant pea cytosolic ascorbate peroxidase.
    Biochemistry 34: 4331-4341 (1995). [PMID: 7703247]
  5. Sharp, K. H., Moody, P. C., Brown, K. A., Raven, E. L.
    Crystal structure of the ascorbate peroxidase-salicylhydroxamic acid complex.
    Biochemistry 43: 8644-8651 (2004). [PMID: 15236572]
  6. Macdonald, I. K., Badyal, S. K., Ghamsari, L., Moody, P. C., Raven, E. L.
    Interaction of ascorbate peroxidase with substrates: a mechanistic and structural analysis.
    Biochemistry 45: 7808-7817 (2006). [PMID: 16784232]

[EC 1.11.1.11 created 1983, modified 2011]