EC - o-aminophenol oxidase

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IntEnz Enzyme Nomenclature


Accepted name:
o-aminophenol oxidase
Other names:
o-aminophenol:O2 oxidoreductase
isophenoxazine synthase
2-aminophenol:O2 oxidoreductase
Systematic name:
2-aminophenol:oxygen oxidoreductase




A flavoprotein which catalyses a 6-electron oxidation. The enzyme from the plant Tecoma stans requires Mn2+ and FAD [1] whereas the fungus Pycnoporus coccineus requires Mn2+ and riboflavin 5'-phosphate [2], the bacteria Streptomyces lividans requires Cu2+ [4] and the plant Bauhenia monandra does not require any co-factors [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050149
CAS Registry Number: 9013-85-8


  1. Nair, P.M. and Vaidynathan, C.S.
    Isophenoxazine synthase.
    Biochim. Biophys. Acta 81 : 507-516 (1964). [PMID: 14170322]
  2. Nair, P.M. and Vining, L.C.
    Isophenoxazine sythase apoenzyme from Pycnoporus coccineus.
    Biochim. Biophys. Acta 96 : 318-327 (1965). [PMID: 14298835]
  3. Subba Rao, P.V. and Vaidyanathan C.S.
    Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra.
    Arch. Biochem. Biophys. 118 : 388-394 (1967). [PMID: 4166439]
  4. Barry, C. E., Nayar, P. G., Begley, T. P.
    Phenoxazinone synthase: mechanism for the formation of the phenoxazinone chromophore of actinomycin.
    Biochemistry 28 : 6323-6333 (1989). [PMID: 2477054]

[EC created 1972, modified 2006]