EC 1.1.99.6 - D-lactate dehydrogenase (acceptor)

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IntEnz Enzyme Nomenclature
EC 1.1.99.6

Names

Accepted name:
D-lactate dehydrogenase (acceptor)
Other names:
2-hydroxy acid dehydrogenase
D-2-hydroxy-acid dehydrogenase
(R)-2-hydroxy-acid:acceptor 2-oxidoreductase
Systematic name:
(R)-lactate:acceptor 2-oxidoreductase

Reaction

Cofactors

Comments:

The zinc flavoprotein (FAD) from the archaeon Archaeoglobus fulgidus cannot utilize NAD+, cytochrome C, methylene blue or dimethylnaphthoquinone as acceptors. In vitro it is active with artificial electron acceptors such as 2,6-dichlorophenolindophenol, but the physiological acceptor is not yet known.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047809
CAS Registry Number: 9028-83-5
UniProtKB/Swiss-Prot:

References

  1. Reed, D. W., Hartzell, P. L.
    The Archaeoglobus fulgidus D-lactate dehydrogenase is a Zn(2+) flavoprotein.
    J. Bacteriol. 181: 7580-7587 (1999). [PMID: 10601217]

[EC 1.1.99.6 created 1965, modified 2013]