EC 1.1.99.39 - D-2-hydroxyglutarate dehydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 1.1.99.39

Names

Accepted name:
D-2-hydroxyglutarate dehydrogenase
Other name:
D-2HGDH (gene name)
Systematic name:
(R)-2-hydroxyglutarate:acceptor 2-oxidoreductase

Reaction

Cofactor

Comments:

Contains FAD. The enzyme has no activity with NAD+ or NADP+, and was assayed in vitro using artificial electron acceptors. It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers. The mammalian enzyme is stimulated by Zn2+, Co2+ and Mn2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0051990
UniProtKB/Swiss-Prot:

References

  1. Engqvist, M., Drincovich, M. F., Flugge, U. I., Maurino, V. G.
    Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways.
    J. Biol. Chem. 284: 25026-25037 (2009). [PMID: 19586914]
  2. Achouri, Y., Noel, G., Vertommen, D., Rider, M. H., Veiga-Da-Cunha, M., Van Schaftingen, E.
    Identification of a dehydrogenase acting on D-2-hydroxyglutarate.
    Biochem. J. 381: 35-42 (2004). [PMID: 15070399]

[EC 1.1.99.39 created 2013]