EC 188.8.131.52 - D-2-hydroxyglutarate dehydrogenase
IntEnz Enzyme Nomenclature
- (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor
Contains FAD. The enzyme has no activity with NAD+ or NADP+, and was assayed in vitro using artificial electron acceptors. It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers. The mammalian enzyme is stimulated by Zn2+, Co2+ and Mn2+.
Links to other databases
Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways.J. Biol. Chem. 284 : 25026-25037 (2009). [PMID: 19586914]
Identification of a dehydrogenase acting on D-2-hydroxyglutarate.Biochem. J. 381 : 35-42 (2004). [PMID: 15070399]
[EC 184.108.40.206 created 2013]