EC - Malate dehydrogenase (quinone)

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IntEnz Enzyme Nomenclature


Accepted name:
malate dehydrogenase (quinone)
Other names:
FAD-dependent malate-vitamin K reductase
malate-vitamin K reductase
(S)-malate:(acceptor) oxidoreductase
L-malate-quinone oxidoreductase
malate:quinone oxidoreductase
malate quinone oxidoreductase
malate:quinone reductase
malate dehydrogenase (acceptor)
FAD-dependent malate dehydrogenase
Systematic name:
(S)-malate:quinone oxidoreductase




A flavoprotein (FAD). Vitamin K and several other quinones can act as acceptors. Different from EC (malate dehydrogenase (NAD+)), EC [malate dehydrogenase (NADP+)] and EC (malate dehydrogenase [NAD(P)+]).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052589 , GO:0008924
CAS Registry Number: 71822-24-7
UniProtKB/Swiss-Prot: (184) [show] [UniProt]


  1. Imai, K. and Brodie, A.F.
    A phospholipid-requiring enzyme, malate-vitamin K reductase.
    J. Biol. Chem. 248 : 7487-7494 (1973).
  2. Imai, T.
    FAD-dependent malate dehydrogenase, a phospholipid-requiring enzyme from Mycobacterium sp. strain Takeo. Purification and some properties.
    Biochim. Biophys. Acta 523 : 37-46 (1978). [PMID: 629992]
  3. Reddy, T.L.P., Murthy, P.S. and Venkitasubramanian, T.A.
    Variations in the pathways of malate oxidation and phosphorylation in different species of Mycobacteria.
    Biochim. Biophys. Acta 376 : 210-218 (1975). [PMID: 234747]
  4. Molenaar, D., van der Rest, M.E., Petrovic, S.
    Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum.
    Eur. J. Biochem. 254 : 395-403 (1998). [PMID: 9660197]
  5. Kather, B., Stingl, K., van der Rest, M.E., Altendorf, K., Molenaar, D.
    Another unusual type of citric acid cycle enzyme in Helicobacter pylori: the malate:quinone oxidoreductase.
    J. Bacteriol. 182 : 3204-3209 (2000). [PMID: 10809701]

[EC, created 1978 as EC, transferred 2009 to EC]