EC 1 - Oxidoreductases
EC 1.1 - Acting on the CH-OH group of donors
EC 1.1.5 - With a quinone or similar compound as acceptor
EC 1.1.5.4 - Malate dehydrogenase (quinone)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.1.5.4
Names
Accepted name:
malate dehydrogenase (quinone)
Other
names:
FAD-dependent malate-vitamin K reductase
malate-vitamin K reductase
(S)-malate:(acceptor) oxidoreductase
L-malate-quinone oxidoreductase
malate:quinone oxidoreductase
malate quinone oxidoreductase
MQO
malate:quinone reductase
malate dehydrogenase (acceptor)
FAD-dependent malate dehydrogenase
malate-vitamin K reductase
(S)-malate:(acceptor) oxidoreductase
L-malate-quinone oxidoreductase
malate:quinone oxidoreductase
malate quinone oxidoreductase
MQO
malate:quinone reductase
malate dehydrogenase (acceptor)
FAD-dependent malate dehydrogenase
Systematic name:
(S)-malate:quinone oxidoreductase
Reaction
- (S)-malate + a quinone = oxaloacetate + reduced quinone
Cofactor
Comments:
A flavoprotein (FAD). Vitamin K and several other quinones can act as acceptors. Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 [malate dehydrogenase (NADP+)] and EC 1.1.1.299 (malate dehydrogenase [NAD(P)+]).
Links to other databases
Gene Ontology:
GO:0052589
,
GO:0008924
CAS Registry Number:
71822-24-7
References
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A phospholipid-requiring enzyme, malate-vitamin K reductase.J. Biol. Chem. 248 : 7487-7494 (1973).
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FAD-dependent malate dehydrogenase, a phospholipid-requiring enzyme from Mycobacterium sp. strain Takeo. Purification and some properties.Biochim. Biophys. Acta 523 : 37-46 (1978). [PMID: 629992]
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Variations in the pathways of malate oxidation and phosphorylation in different species of Mycobacteria.Biochim. Biophys. Acta 376 : 210-218 (1975). [PMID: 234747]
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Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum.Eur. J. Biochem. 254 : 395-403 (1998). [PMID: 9660197]
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Another unusual type of citric acid cycle enzyme in Helicobacter pylori: the malate:quinone oxidoreductase.J. Bacteriol. 182 : 3204-3209 (2000). [PMID: 10809701]
[EC 1.1.5.4, created 1978 as EC 1.1.99.16, transferred 2009 to EC 1.1.5.4]