EC - (S)-2-hydroxyglutarate dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
(S)-2-hydroxyglutarate dehydrogenase
Other name:
L-2-hydroxyglutarate dehydrogenase
Systematic name:
(S)-2-hydroxyglutarate:quinone oxidoreductase



The enzyme, characterized from the bacterium Escherichia coli, contains an FAD cofactor that is not covalently attached. It is bound to the cytoplasmic membrane and is coupled to the membrane quinone pool.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Kalliri, E., Mulrooney, S. B., Hausinger, R. P.
    Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase.
    J. Bacteriol. 190 : 3793-3798 (2008). [PMID: 18390652]
  2. Knorr, S., Sinn, M., Galetskiy, D., Williams, R. M., Wang, C., Muller, N., Mayans, O., Schleheck, D., Hartig, J. S.
    Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate.
    Nat Commun 9 : 5071 (2018). [PMID: 30498244]

[EC created 2019]