EC 1.1.3.46 - 4-hydroxymandelate oxidase

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IntEnz Enzyme Nomenclature
EC 1.1.3.46

Names

Accepted name:
4-hydroxymandelate oxidase
Other names:
4HmO
HmO
Systematic name:
(S)-4-hydroxymandelate:oxygen 1-oxidoreductase

Reaction

Cofactor

Comments:

A flavoprotein (FMN). The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Hubbard, B. K., Thomas, M. G., Walsh, C. T.
    Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
    Chem. Biol. 7 : 931-942 (2000). [PMID: 11137816]
  2. Li, T. L., Choroba, O. W., Charles, E. H., Sandercock, A. M., Williams, D. H., Spencer, J. B.
    Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics.
    Chem. Commun. (Camb.) 1752-1753 (2001). [PMID: 12240298]

[EC 1.1.3.46 created 2014]