EC - Vanillyl-alcohol oxidase

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IntEnz Enzyme Nomenclature


Accepted name:
vanillyl-alcohol oxidase
Other name:
4-hydroxy-2-methoxybenzyl alcohol oxidase
Systematic name:
vanillyl alcohol:oxygen oxidoreductase




Vanillyl-alcohol oxidase from Penicillium simplicissimum contains covalently bound FAD. It converts a wide range of 4-hydroxybenzyl alcohols and 4-hydroxybenzylamines into the corresponding aldehydes. The allyl group of 4-allylphenols is also converted into the -CH=CH-CH2OH group.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018465
CAS Registry Number: 143929-24-2


  1. de Jong, E., van Berkel, W.J.H., van der Zwan, R.P. and de Bont, J.A.M.
    Purification and characterization of vanillyl-alcohol oxidase from Penicillium simplicissimum, a novel aromatic alcohol oxidase containing covalently bound FAD.
    Eur. J. Biochem. 208 : 651-657 (1992). [PMID: 1396672]
  2. Fraaije, M.W., Veeger, C. and van Berkel, W.J.H.
    Substrate specificity of flavin-dependent vanillyl-alcohol oxidase from Penicillium simplicissimum. Evidence for the production of 4-hydroxycinnamyl alcohols from 4-allylphenols.
    Eur. J. Biochem. 234 : 271-277 (1995). [PMID: 8529652]

[EC created 1999]