EC - Nucleoside oxidase

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IntEnz Enzyme Nomenclature


Accepted name:
nucleoside oxidase
Systematic name:
nucleoside:oxygen 5'-oxidoreductase



Other purine and pyrimidine nucleosides (as well as 2'-deoxyribonucleosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC, nucleoside oxidase (H2O2-forming), as it produces water rather than hydrogen peroxide.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033715


  1. Isono, Y., Sudo, T. and Hoshino, M.
    Purification and reaction of a new enzyme, nucleoside oxidase.
    Agric. Biol. Chem. 53: 1663-1669 (1989).
  2. Isono, Y., Sudo, T. and Hoshino, M.
    Properties of a new enzyme, nucleoside oxidase, from Pseudomonas maltophilia LB-86.
    Agric. Biol. Chem. 53: 1671-1677 (1989).

[EC created 1992, modified 2001]