EC 126.96.36.199 - Alcohol oxidase
IntEnz Enzyme Nomenclature
19829 [IUBMB]a primary alcohola primary alcoholName origin: UniProt - CHECKED (C)Formula: CH3OR
Charge: 0ChEBI compound status: CHECKED (C)O2O2Name origin: UniProt - CHECKED (C)Formula: O2
Charge: 0ChEBI compound status: CHECKED (C)=an aldehydean aldehydeName origin: UniProt - CHECKED (C)Formula: CHOR
Charge: 0ChEBI compound status: CHECKED (C)
The enzymes from the fungi Candida methanosorbosa and several Basidiomycetes species contain an FAD cofactor [1,3]. The enzyme from the phytopathogenic fungi Colletotrichum graminicola and Colletotrichum gloeosporioides utilize a mononuclear copper-radical mechanism . The enzyme acts on primary alcohols and unsaturated alcohols, and has much lower activity with branched-chain and secondary alcohols.
Links to other databases
Alcohol oxidase, a flavoprotein from several Basidiomycetes species. Crystallization by fractional precipitation with polyethylene glycol.Biochim. Biophys. Acta 151: 330-342 (1968). [PMID: 5636370]
Studies on enzymes related to lignan biodegradation. (in Japanese)Baiomasu Henkan Keikaku Kenkyu Hokoku 38-59 (1987).
Purification and properties of alcohol oxidase from Candida methanosorbosa M-2003.Curr. Microbiol. 34: 374-377 (1997). [PMID: 9142745]
Structure-function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family.Nat. Commun. 6: 10197 (2015). [PMID: 26680532]
[EC 188.8.131.52 created 1972]