EC - Alcohol oxidase

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IntEnz Enzyme Nomenclature


Accepted name:
alcohol oxidase
Other names:
ethanol oxidase
methanol oxidase
Systematic name:
alcohol:oxygen oxidoreductase




The enzymes from the fungi Candida methanosorbosa and several Basidiomycetes species contain an FAD cofactor [1,3]. The enzyme from the phytopathogenic fungi Colletotrichum graminicola and Colletotrichum gloeosporioides utilize a mononuclear copper-radical mechanism [4]. The enzyme acts on primary alcohols and unsaturated alcohols, and has much lower activity with branched-chain and secondary alcohols.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00543
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047639
CAS Registry Number: 9073-63-6


  1. Janssen, F.W. and Ruelius, H.W.
    Alcohol oxidase, a flavoprotein from several Basidiomycetes species. Crystallization by fractional precipitation with polyethylene glycol.
    Biochim. Biophys. Acta 151: 330-342 (1968). [PMID: 5636370]
  2. Nishida, A., Ishihara, T. and Hiroi, T.
    Studies on enzymes related to lignan biodegradation. (in Japanese)
    Baiomasu Henkan Keikaku Kenkyu Hokoku 38-59 (1987).
  3. Suye, S.
    Purification and properties of alcohol oxidase from Candida methanosorbosa M-2003.
    Curr. Microbiol. 34: 374-377 (1997). [PMID: 9142745]
  4. Yin, D.T., Urresti, S., Lafond, M., Johnston, E.M., Derikvand, F., Ciano, L., Berrin, J.G., Henrissat, B., Walton, P.H., Davies, G.J. and Brumer, H.
    Structure-function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family.
    Nat. Commun. 6: 10197 (2015). [PMID: 26680532]

[EC created 1972]