EC 1 - Oxidoreductases
EC 1.1 - Acting on the CH-OH group of donors
EC 1.1.2 - With a cytochrome as acceptor
EC 1.1.2.3 - L-lactate dehydrogenase (cytochrome)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.1.2.3
Names
Accepted name:
L-lactate dehydrogenase (cytochrome)
Other
names:
L(+)-lactate:cytochrome c oxidoreductase
L-lactate cytochrome c oxidoreductase
L-lactate cytochrome c reductase
cytochrome b2 (flavin-free derivative of flavocytochrome b2)
dehydrogenase, lactate (cytochrome)
flavocytochrome b2
lactate dehydrogenase (cytochrome)
lactic acid dehydrogenase
lactic cytochrome c reductase
L-lactate ferricytochrome c oxidoreductase
L-lactate cytochrome c oxidoreductase
L-lactate cytochrome c reductase
cytochrome b2 (flavin-free derivative of flavocytochrome b2)
dehydrogenase, lactate (cytochrome)
flavocytochrome b2
lactate dehydrogenase (cytochrome)
lactic acid dehydrogenase
lactic cytochrome c reductase
L-lactate ferricytochrome c oxidoreductase
Systematic name:
(S)-lactate:ferricytochrome-c 2-oxidoreductase
Reaction
- (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+
Cofactors
Comments:
Identical with cytochrome b2; a flavohemoprotein (FMN).
Links to other databases
Protein domains and families:
PROSITE:PDOC00170
,
PROSITE:PDOC00482
Gene Ontology:
GO:0004460
CAS Registry Number:
9078-32-4
UniProtKB/Swiss-Prot:
References
-
Lactic dehydrogenase and cytochrome b2 of baker's yeast. Purification and crystallization.Biochem. J. 71 : 492-499 (1959). [PMID: 13638255]
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Lactic dehydrogenase and cytochrome b2 of baker's yeast. Enzymic and chemical properties of the crystalline enzyme.Biochem. J. 73 : 539-550 (1959). [PMID: 13793977]
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Yeast lactic dehydrogenase and cytochrome b2.Biochem. J. 40 : 229-239 (1946). [PMID: 16747991]
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Lactate dehydrogenases of yeast.In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes , 2nd ed. vol. 7 , Academic Press , New York , 1963 , 557-565
[EC 1.1.2.3 created 1961]