EC - Phosphoglycerate dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
phosphoglycerate dehydrogenase
Other names:
3-phosphoglycerate dehydrogenase
3-phosphoglyceric acid dehydrogenase
α-phosphoglycerate dehydrogenase
D-3-phosphoglycerate dehydrogenase
D-3-phosphoglycerate:NAD+ oxidoreductase
glycerate 3-phosphate dehydrogenase
glycerate-1,3-phosphate dehydrogenase
phosphoglycerate oxidoreductase
phosphoglyceric acid dehydrogenase
3-phosphoglycerate:NAD+ 2-oxidoreductase
3PHP reductase
αKG reductase
D- and L-HGA
PHGDH (gene name)
SerA 3PG dehydrogenase
Systematic name:
3-phospho-D-glycerate:NAD+ 2-oxidoreductase



This enzyme catalyses the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis. The reaction occurs predominantly in the direction of reduction. The enzyme from the bacterium Escherichia coli also catalyses the activity of EC, 2-oxoglutarate reductase [6].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00063
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004617
CAS Registry Number: 9075-29-0
UniProtKB/Swiss-Prot: (30) [show] [UniProt]


  1. Pizer, L.I.
    The pathway and control of serine biosynthesis in Escherichia coli.
    J. Biol. Chem. 238 : 3934-3944 (1963). [PMID: 14086727]
  2. Walsh, D. A., Sallach, H. J.
    Purification and properties of chicken liver D-3-phosphoglycerate dehydrogenase.
    Biochemistry 4 : 1076-1085 (1965). [PMID: 4378782]
  3. Slaughter, J. C., Davies, D. D.
    The isolation and characterization of 3-phosphoglycerate dehydrogenase from peas.
    Biochem. J. 109 : 743-748 (1968). [PMID: 4386930]
  4. Sugimoto, E., Pizer, L. I.
    The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase.
    J. Biol. Chem. 243 : 2081-2089 (1968). [PMID: 4384871]
  5. Schuller, D. J., Grant, G. A., Banaszak, L. J.
    The allosteric ligand site in the Vmax-type cooperative enzyme phosphoglycerate dehydrogenase.
    Nat. Struct. Biol. 2 : 69-76 (1995). [PMID: 7719856]
  6. Zhao, G., Winkler, M. E.
    A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria.
    J. Bacteriol. 178 : 232-239 (1996). [PMID: 8550422]
  7. Achouri, Y., Rider, M. H., Schaftingen, E. V., Robbi, M.
    Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenase.
    Biochem. J. 323 ( Pt 2) : 365-370 (1997). [PMID: 9163325]
  8. Dey, S., Grant, G. A., Sacchettini, J. C.
    Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits.
    J. Biol. Chem. 280 : 14892-14899 (2005). [PMID: 15668249]

[EC created 1972, modified 2006, modified 2016]