EC 1 - Oxidoreductases
EC 1.1 - Acting on the CH-OH group of donors
EC 1.1.1 - With NAD+ or NADP+ as acceptor
EC 1.1.1.86 - Ketol-acid reductoisomerase (NADP+)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.1.1.86
Names
Accepted name:
ketol-acid reductoisomerase (NADP+)
Other
names:
2-hydroxy-3-keto acid reductoisomerase
α-keto-β-hydroxylacyl reductoisomerase
acetohydroxy acid isomeroreductase
acetohydroxy acid reductoisomerase
acetolactate reductoisomerase
dihydroxyisovalerate (isomerizing) dehydrogenase
dihydroxyisovalerate dehydrogenase (isomerizing)
isomeroreductase
ketol acid reductoisomerase
reductoisomerase
ketol-acid reductoisomerase
(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
α-keto-β-hydroxylacyl reductoisomerase
acetohydroxy acid isomeroreductase
acetohydroxy acid reductoisomerase
acetolactate reductoisomerase
dihydroxyisovalerate (isomerizing) dehydrogenase
dihydroxyisovalerate dehydrogenase (isomerizing)
isomeroreductase
ketol acid reductoisomerase
reductoisomerase
ketol-acid reductoisomerase
(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
Systematic name:
(2R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
Reactions
- (1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
- (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
Comments:
Also catalyses the reduction of 2-ethyl-2-hydroxy-3-oxobutanoate to 2,3-dihydroxy-3-methylpentanoate. The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382, ketol-acid reductoisomerase (NAD+) and EC 1.1.1.383, ketol-acid reductoisomerase [NAD(P)+]).
Links to other databases
Gene Ontology:
GO:0004455
ILV5_ARATH
ILV5_NEUCR
ILV5_ORYSJ
ILV5_PEA
ILV5_POPEU
ILV5_SCHPO
ILV5_SPIOL
ILV5_YEAST
ILVC1_BACAN
ILVC1_BACC1
ILVC1_BACCR
ILVC1_BACCZ
ILVC1_BACHK
ILVC1_BIFLO
ILVC1_STRCO
ILVC2_BACAN
ILVC2_BACC1
ILVC2_BACCR
ILVC2_BACCZ
ILVC2_BACHK
ILVC2_BIFLO
ILVC2_SACS2
ILVC2_STRCO
ILVC3_SACS2
ILVC_ACAM1
ILVC_ACET2
ILVC_ACIAC
ILVC_ACIAD
ILVC_ACIB3
ILVC_ACIB5
ILVC_ACIBC
ILVC_ACIBS
ILVC_ACIBT
ILVC_ACIBY
ILVC_ACIC5
ILVC_ACICJ
ILVC_ACIET
ILVC_ACIF2
ILVC_ACIF5
ILVC_ACISJ
ILVC_ACTP2
ILVC_ACTPJ
ILVC_ACTSZ
ILVC_AERHH
ILVC_AERS4
ILVC_AFIC5
ILVC_AGRFC
ILVC_AGRRK
ILVC_AGRVS
ILVC_AKKM8
ILVC_ALCBS
ILVC_ALIAD
ILVC_ALIB4
ILVC_ALIF1
ILVC_ALIFM
ILVC_ALISL
ILVC_ALKEH
ILVC_ALKHC
ILVC_ALKMQ
ILVC_ALTMD
ILVC_ANAD2
ILVC_ANADE
ILVC_ANASK
ILVC_ANOFW
ILVC_AQUAE
ILVC_AROAE
ILVC_ARTS2
ILVC_AZOC5
ILVC_AZOSB
ILVC_AZOVD
ILVC_BACCN
ILVC_BACLD
ILVC_BACP2
ILVC_BACSK
ILVC_BACSU
ILVC_BACVZ
ILVC_BARBK
ILVC_BARHE
ILVC_BARQU
ILVC_BART1
ILVC_BEII9
ILVC_BEUC1
ILVC_BIFA0
ILVC_BLOFL
ILVC_BLOPB
ILVC_BORA1
ILVC_BORBR
ILVC_BORPA
ILVC_BORPD
ILVC_BORPE
ILVC_BRADU
ILVC_BRAHW
ILVC_BRASB
ILVC_BRASO
ILVC_BREBN
ILVC_BRUA1
ILVC_BRUA2
ILVC_BRUA4
ILVC_BRUAB
ILVC_BRUC2
ILVC_BRUMB
ILVC_BRUME
ILVC_BRUO2
ILVC_BRUSI
ILVC_BRUSU
ILVC_BUCA5
ILVC_BUCAI
ILVC_BUCAP
ILVC_BUCAT
ILVC_BUCBP
ILVC_BUCDN
ILVC_BUCMH
ILVC_BUCML
ILVC_BUCSC
ILVC_BUCUE
ILVC_BUCUL
ILVC_BUCUM
ILVC_BUCUN
ILVC_BURA4
ILVC_BURCA
ILVC_BURCC
ILVC_BURCH
ILVC_BURCJ
ILVC_BURCM
ILVC_BURL3
ILVC_BURM1
ILVC_BURM7
ILVC_BURM9
ILVC_BURMA
ILVC_BURMS
ILVC_BURP0
ILVC_BURP1
ILVC_BURP6
ILVC_BURPS
ILVC_BURTA
ILVC_BURVG
ILVC_CALBD
ILVC_CALMQ
ILVC_CALS4
ILVC_CALS8
ILVC_CAMC1
ILVC_CAMC5
ILVC_CAMFF
ILVC_CAMHC
ILVC_CAMJ8
ILVC_CAMJD
ILVC_CAMJE
ILVC_CAMJJ
ILVC_CAMJR
ILVC_CAMLR
ILVC_CARHZ
ILVC_CAUSK
ILVC_CAUVC
ILVC_CAUVN
ILVC_CELJU
ILVC_CENSY
ILVC_CERS4
ILVC_CERS5
ILVC_CHESB
ILVC_CHLAA
ILVC_CHLAD
ILVC_CHLCH
ILVC_CHLL2
ILVC_CHLL3
ILVC_CHLPB
ILVC_CHLPD
ILVC_CHLPM
ILVC_CHLSY
ILVC_CHLT3
ILVC_CHLTE
ILVC_CHRSD
ILVC_CHRVO
ILVC_CITK8
ILVC_CLAM3
ILVC_CLAMS
ILVC_CLOAB
ILVC_CLOB8
ILVC_CLOBA
ILVC_CLOBB
ILVC_CLOD6
ILVC_CLONN
ILVC_COLP3
ILVC_CORA7
ILVC_CORDI
ILVC_COREF
ILVC_CORGB
ILVC_CORGL
ILVC_CORJK
ILVC_CORK4
ILVC_CORU7
ILVC_CROS5
ILVC_CROS8
ILVC_CUPMC
ILVC_CUPNH
ILVC_CUPPJ
ILVC_CUPTR
ILVC_CUTAK
ILVC_CYAP4
ILVC_CYTH3
ILVC_DECAR
ILVC_DEHM1
ILVC_DEHMB
ILVC_DEHMC
ILVC_DEIDV
ILVC_DEIGD
ILVC_DEIRA
ILVC_DELAS
ILVC_DESAG
ILVC_DESDA
ILVC_DESHD
ILVC_DESHY
ILVC_DESMR
ILVC_DESRM
ILVC_DESVH
ILVC_DESVM
ILVC_DESVV
ILVC_DICT6
ILVC_DICTD
ILVC_DINSH
ILVC_ECO24
ILVC_ECO27
ILVC_ECO45
ILVC_ECO55
ILVC_ECO57
ILVC_ECO5E
ILVC_ECO7I
ILVC_ECO81
ILVC_ECO8A
ILVC_ECOBW
ILVC_ECODH
ILVC_ECOHS
ILVC_ECOK1
ILVC_ECOL5
ILVC_ECOL6
ILVC_ECOLC
ILVC_ECOLI
ILVC_ECOLU
ILVC_ECOSE
ILVC_ECOSM
ILVC_ECOUT
ILVC_EDWI9
ILVC_ENT38
ILVC_ERWT9
ILVC_ERYLH
ILVC_ESCF3
ILVC_FLAJ1
ILVC_FRAAA
ILVC_FRACC
ILVC_FRASN
ILVC_GEODF
ILVC_GEOKA
ILVC_GEOLS
ILVC_GEOMG
ILVC_GEOSL
ILVC_GEOSW
ILVC_GEOTN
ILVC_GEOUR
ILVC_GLOC7
ILVC_GLOVI
ILVC_GLUDA
ILVC_GLUOX
ILVC_GRABC
ILVC_GRAFK
ILVC_HAEI8
ILVC_HAEIE
ILVC_HAEIG
ILVC_HAEIN
ILVC_HAEPS
ILVC_HAES1
ILVC_HAHCH
ILVC_HALHL
ILVC_HALMA
ILVC_HALOH
ILVC_HALWD
ILVC_HELAH
ILVC_HELHP
ILVC_HELMI
ILVC_HELP2
ILVC_HELPH
ILVC_HELPJ
ILVC_HELPS
ILVC_HELPY
ILVC_HERA2
ILVC_HERAR
ILVC_HISS2
ILVC_HYDCU
ILVC_HYPNA
ILVC_JANMA
ILVC_JANSC
ILVC_KINRD
ILVC_KLEP3
ILVC_KLEP7
ILVC_KOCRD
ILVC_KORVE
ILVC_LACLA
ILVC_LACLM
ILVC_LACLS
ILVC_LACP7
ILVC_LARHH
ILVC_LEIXX
ILVC_LEPBA
ILVC_LEPBJ
ILVC_LEPBL
ILVC_LEPBP
ILVC_LEPCP
ILVC_LEPIC
ILVC_LEPIN
ILVC_LEUMC
ILVC_LEUMM
ILVC_LISIN
ILVC_LISMC
ILVC_LISMF
ILVC_LISMH
ILVC_LISMO
ILVC_LISW6
ILVC_LYSSC
ILVC_MACCJ
ILVC_MAGML
ILVC_MAGMM
ILVC_MAGSA
ILVC_MANSM
ILVC_MARMS
ILVC_MARN8
ILVC_MARSD
ILVC_METAC
ILVC_METAR
ILVC_METB6
ILVC_METBF
ILVC_METBU
ILVC_METC4
ILVC_METCA
ILVC_METEP
ILVC_METFK
ILVC_METHJ
ILVC_METJA
ILVC_METKA
ILVC_METLZ
ILVC_METM5
ILVC_METM6
ILVC_METM7
ILVC_METMA
ILVC_METMJ
ILVC_METMP
ILVC_METNO
ILVC_METPB
ILVC_METPE
ILVC_METPP
ILVC_METRJ
ILVC_METS3
ILVC_METS4
ILVC_METSB
ILVC_METST
ILVC_METTH
ILVC_METTP
ILVC_METVS
ILVC_MICAN
ILVC_MOOTA
ILVC_MYCA1
ILVC_MYCAV
ILVC_MYCBO
ILVC_MYCBP
ILVC_MYCGI
ILVC_MYCLE
ILVC_MYCPA
ILVC_MYCS2
ILVC_MYCSJ
ILVC_MYCSK
ILVC_MYCSS
ILVC_MYCTA
ILVC_MYCTO
ILVC_MYCTU
ILVC_MYCUA
ILVC_MYCVP
ILVC_NATPD
ILVC_NEIG1
ILVC_NEIM0
ILVC_NEIMA
ILVC_NEIMB
ILVC_NEIMF
ILVC_NITEC
ILVC_NITEU
ILVC_NITHX
ILVC_NITMS
ILVC_NITMU
ILVC_NITOC
ILVC_NITSB
ILVC_NITWN
ILVC_NOCFA
ILVC_NOSP7
ILVC_NOSS1
ILVC_NOVAD
ILVC_OCEIH
ILVC_PARDP
ILVC_PARL1
ILVC_PARMW
ILVC_PARP8
ILVC_PARPJ
ILVC_PARXL
ILVC_PASMU
ILVC_PECAS
ILVC_PECCP
ILVC_PELPB
ILVC_PELPD
ILVC_PELUB
ILVC_PERMH
ILVC_PETMO
ILVC_PHEZH
ILVC_PHOLL
ILVC_PHOPR
ILVC_POLAQ
ILVC_POLNA
ILVC_POLNS
ILVC_POLSJ
ILVC_PRB01
ILVC_PROA2
ILVC_PROM0
ILVC_PROM1
ILVC_PROM2
ILVC_PROM3
ILVC_PROM4
ILVC_PROM5
ILVC_PROM9
ILVC_PROMA
ILVC_PROMH
ILVC_PROMM
ILVC_PROMP
ILVC_PROMS
ILVC_PROMT
ILVC_PSE14
ILVC_PSEA6
ILVC_PSEA7
ILVC_PSEA8
ILVC_PSEAB
ILVC_PSEAE
ILVC_PSECP
ILVC_PSEE4
ILVC_PSEF5
ILVC_PSEFS
ILVC_PSEMY
ILVC_PSEP1
ILVC_PSEPF
ILVC_PSEPG
ILVC_PSEPK
ILVC_PSEPW
ILVC_PSESM
ILVC_PSET1
ILVC_PSEU2
ILVC_PSEU5
ILVC_PSYA2
ILVC_PSYCK
ILVC_PSYWF
ILVC_PYRAB
ILVC_PYRAE
ILVC_PYRAR
ILVC_PYRCJ
ILVC_PYRFU
ILVC_PYRIL
ILVC_PYRNV
ILVC_RALPJ
ILVC_RALSO
ILVC_RENSM
ILVC_RHIE6
ILVC_RHIEC
ILVC_RHIL3
ILVC_RHILO
ILVC_RHILW
ILVC_RHIME
ILVC_RHOBA
ILVC_RHOCS
ILVC_RHOE4
ILVC_RHOFT
ILVC_RHOJR
ILVC_RHOOB
ILVC_RHOP2
ILVC_RHOP5
ILVC_RHOPA
ILVC_RHOPB
ILVC_RHOPS
ILVC_RHOPT
ILVC_RHORT
ILVC_RHOS1
ILVC_RHOSK
ILVC_RIPO1
ILVC_ROSCS
ILVC_ROSDO
ILVC_RUBXD
ILVC_RUEPO
ILVC_RUEST
ILVC_RUMCH
ILVC_RUTMC
ILVC_SACD2
ILVC_SACEN
ILVC_SACS2
ILVC_SALA4
ILVC_SALAI
ILVC_SALAR
ILVC_SALCH
ILVC_SALDC
ILVC_SALEP
ILVC_SALG2
ILVC_SALHS
ILVC_SALNS
ILVC_SALPA
ILVC_SALPB
ILVC_SALPC
ILVC_SALPK
ILVC_SALRD
ILVC_SALSV
ILVC_SALTI
ILVC_SALTO
ILVC_SALTY
ILVC_SERP5
ILVC_SHEAM
ILVC_SHEON
ILVC_SHIB3
ILVC_SHIBS
ILVC_SHIDS
ILVC_SHIFL
ILVC_SHISS
ILVC_SINFN
ILVC_SINMW
ILVC_SLAES
ILVC_SODGM
ILVC_SOLUE
ILVC_SORC5
ILVC_SPHAL
ILVC_SPHWW
ILVC_STAA1
ILVC_STAA2
ILVC_STAA3
ILVC_STAA8
ILVC_STAA9
ILVC_STAAB
ILVC_STAAC
ILVC_STAAE
ILVC_STAAM
ILVC_STAAN
ILVC_STAAR
ILVC_STAAS
ILVC_STAAT
ILVC_STAAW
ILVC_STACT
ILVC_STAEQ
ILVC_STAES
ILVC_STAHJ
ILVC_STAS1
ILVC_STRAW
ILVC_STRGC
ILVC_STRGG
ILVC_STRMU
ILVC_STRP2
ILVC_STRP4
ILVC_STRP7
ILVC_STRPI
ILVC_STRPJ
ILVC_STRPN
ILVC_STRPS
ILVC_STRR6
ILVC_STRS2
ILVC_STRSV
ILVC_STRSY
ILVC_STRT1
ILVC_STRT2
ILVC_STRTD
ILVC_STRTR
ILVC_STRZJ
ILVC_STRZP
ILVC_STRZT
ILVC_SULAC
ILVC_SULDN
ILVC_SULIA
ILVC_SULIK
ILVC_SULIL
ILVC_SULIM
ILVC_SULIN
ILVC_SULIY
ILVC_SULSY
ILVC_SULTO
ILVC_SYNE7
ILVC_SYNJA
ILVC_SYNJB
ILVC_SYNP2
ILVC_SYNP6
ILVC_SYNPW
ILVC_SYNR3
ILVC_SYNS3
ILVC_SYNS9
ILVC_SYNSC
ILVC_SYNY3
ILVC_TERTT
ILVC_THEFY
ILVC_THEMA
ILVC_THENN
ILVC_THEP1
ILVC_THEP3
ILVC_THEPX
ILVC_THERP
ILVC_THESQ
ILVC_THET2
ILVC_THET8
ILVC_THEVB
ILVC_THEYD
ILVC_THIDA
ILVC_THISH
ILVC_TOLAT
ILVC_TREPR
ILVC_TRIEI
ILVC_TRIV2
ILVC_TROW8
ILVC_TROWT
ILVC_VARPS
ILVC_VESOH
ILVC_VIBA3
ILVC_VIBC3
ILVC_VIBCH
ILVC_VIBCM
ILVC_VIBPA
ILVC_VIBVU
ILVC_VIBVY
ILVC_WOLSU
ILVC_XANAC
ILVC_XANC5
ILVC_XANC8
ILVC_XANCB
ILVC_XANCP
ILVC_XANOM
ILVC_XANOP
ILVC_XANOR
ILVC_XANP2
ILVC_XYLFA
ILVC_XYLFT
ILVC_YERE8
ILVC_YERP3
ILVC_YERPA
ILVC_YERPB
ILVC_YERPE
ILVC_YERPG
ILVC_YERPN
ILVC_YERPP
ILVC_YERPS
ILVC_YERPY
ILVC_ZYMMO
References
-
Arfin, S.M. and Umbarger, H.E.Purification and properties of the acetohydroxy acid isomeroreductase of Salmonella typhimurium.J. Biol. Chem. 244 : 1118-1127 (1969). [PMID: 4388025]
-
Hill, R.K., Sawada, S. and Arfin, S.M.Stereochemistry of valine and isoleucine biosynthesis. IV. Synthesis, configuration, and enzymatic specificity of α-acetolactate and α-aceto-α-hydroxybutyrate.Bioorg. Chem. 8 : 175-189 (1979).
-
Kiritani, K., Narise, S. and Wagner, R.P.The reductoisomerase of Neurospora crassa.J. Biol. Chem. 241 : 2047-2051 (1966).
-
Satyanarayana, T. and Radhakrishnan, A.N.Biosynthesis of valine and isoleucine in plants. 3. Reductoisomerase of Phaseolus radiatus.Biochim. Biophys. Acta 110 : 380-388 (1965). [PMID: 5866387]
-
Brinkmann-Chen, S., Cahn, J. K., Arnold, F. H.Uncovering rare NADH-preferring ketol-acid reductoisomerases.Metab. Eng. 26C : 17-22 (2014). [PMID: 25172159]
[EC 1.1.1.86 created 1972, modified 1976, modified 1981 (EC 1.1.1.89 created 1972, incorporated 1976), modified 2015]