EC - Malate dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature


Accepted name:
malate dehydrogenase (NADP+)
Other names:
NADP malate dehydrogenase
NADP-linked malate dehydrogenase
NADP-malate dehydrogenase
NADP-malic enzyme
malate NADP dehydrogenase
malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)
Systematic name:
(S)-malate:NADP+ oxidoreductase



Activated by light.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00066
Structural data: CSA , EC2PDB
Gene Ontology: GO:0046554
CAS Registry Number: 37250-19-4
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Connelly, J.L., Danner, D.J. and Bowden, J.A.
    Branched chain α-keto acid metabolism. I. Isolation, purification, and partial characterization of bovine liver α-ketoisocaproic:α-keto-β-methylvaleric acid dehydrogenase.
    J. Biol. Chem. 243 : 1198-1203 (1968). [PMID: 5689906]
  2. Johnson, H.S.
    NADP-malate dehydrogenase: photoactivation in leaves of plants with Calvin cycle photosynthesis.
    Biochem. Biophys. Res. Commun. 43 : 703-709 (1971). [PMID: 4397919]
  3. Johnson, H.S. and Hatch, M.D.
    Properties and regulation of leaf nicotinamide-adenine dinucleotide phosphate-malate dehydrogenase and 'malic' enzyme in plants with the C4-dicarboxylic acid pathway of photosynthesis.
    Biochem. J. 119 : 273-280 (1970). [PMID: 4395182]

[EC created 1972]