EC - Glycerol-3-phosphate dehydrogenase (NAD+)

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IntEnz Enzyme Nomenclature


Accepted name:
glycerol-3-phosphate dehydrogenase (NAD+)
Other names:
α-glycerol phosphate dehydrogenase (NAD)
α-glycerophosphate dehydrogenase (NAD)
L-α-glycerol phosphate dehydrogenase
L-α-glycerophosphate dehydrogenase
L-glycerol phosphate dehydrogenase
L-glycerophosphate dehydrogenase
NAD-α-glycerophosphate dehydrogenase
NAD-L-glycerol-3-phosphate dehydrogenase
NAD-dependent glycerol phosphate dehydrogenase
NAD-dependent glycerol-3-phosphate dehydrogenase
NAD-linked glycerol 3-phosphate dehydrogenase
NADH-dihydroxyacetone phosphate reductase
glycerol 1-phosphate dehydrogenase
glycerol phosphate dehydrogenase (NAD)
glycerophosphate dehydrogenase (NAD)
hydroglycerophosphate dehydrogenase
glycerol-3-phosphate dehydrogenase (NAD)
L-glycerol-3-phosphate dehydrogenase [ambiguous]
Systematic name:
sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase



Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00740
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004367
CAS Registry Number: 9075-65-4
UniProtKB/Swiss-Prot: (60) [show] [UniProt]


  1. Baranowski, T.
    α-Glycerophosphate dehydrogenase.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes , 2nd ed. vol. 7 , Academic Press , New York , 1963 , 85-96
  2. Brosemer, R.W. and Kuhn, R.W.
    Comparative structural properties of honeybee and rabbit α-glycerophosphate dehydrogenases.
    Biochemistry 8 : 2095-2105 (1969). [PMID: 4307630]
  3. O'Brien, S.J. and MacIntyre, R.J.
    The α-glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects.
    Biochem. Genet. 7 : 141-161 (1972). [PMID: 4340553]
  4. Warkentin, K.L. and Fondy, T.P.
    Isolation and characterization of cytoplasmic L-glycerol-3-phosphate dehydrogenase from rabbit-renal-adipose tissue and its comparison with the skeletal-muscle enzyme.
    Eur. J. Biochem. 36 : 97-109 (1973). [PMID: 4200180]
  5. Albertyn, J., van Tonder, A. and Prior, B.A.
    Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae.
    FEBS Lett. 308 : 130-132 (1992). [PMID: 1499720]
  6. Koekemoer, T.C., Litthauer, D. and Oelofsen, W.
    Isolation and characterization of adipose tissue glycerol-3-phosphate dehydrogenase.
    Int. J. Biochem. Cell. Biol. 27 : 625-632 (1995). [PMID: 7671141]

[EC created 1961, modified 2005]