EC 1.1.1.78 - Methylglyoxal reductase (NADH)

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IntEnz Enzyme Nomenclature
EC 1.1.1.78

Names

Accepted name:
methylglyoxal reductase (NADH)
Other names:
methylglyoxal reductase
D-lactaldehyde dehydrogenase
methylglyoxal reductase (NADH-dependent)
Systematic name:
(R)-lactaldehyde:NAD+ oxidoreductase

Reaction

Comments:

This mammalian enzyme differs from the yeast enzyme, EC 1.1.1.283, methylglyoxal reductase (NADPH-dependent), by its coenzyme requirement, reaction direction, and enantiomeric preference.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00061
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019170
CAS Registry Number: 37250-16-1

References

  1. Ting, S.-M., Miller, O.N. and Sellinger, O.Z.
    The metabolism of lactaldehyde. VII. The oxidation of D-lactaldehyde in rat liver.
    Biochim. Biophys. Acta 97: 407-415 (1965). [PMID: 14323585]
  2. Ray, M., Ray, S.
    Purification and partial characterization of a methylglyoxal reductase from goat liver.
    Biochim. Biophys. Acta 802: 119-127 (1984). [PMID: 6386056]

[EC 1.1.1.78 created 1972, modified 2005, modified 2013]