EC - (S,S)-butanediol dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
(S,S)-butanediol dehydrogenase
Other names:
L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)
L-butanediol dehydrogenase
(S)-acetoin reductase [(S,S)-butane-2,3-diol forming]
Systematic name:
(S,S)-butane-2,3-diol:NAD+ oxidoreductase



This enzyme catalyses the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol. It can also catalyse the irreversible reduction of diacetyl to (S)-acetoin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047512


  1. Taylor, M.B. and Juni, E.
    Stereoisomeric specificities of 2,3-butanediol dehydrogenases.
    Biochim. Biophys. Acta 39: 448-457 (1960). [PMID: 13837186]
  2. Carballo, J., Martin, R., Bernardo, A., Gonzalez, J.
    Purification, characterization and some properties of diacetyl(acetoin) reductase from Enterobacter aerogenes.
    Eur. J. Biochem. 198: 327-332 (1991). [PMID: 2040298]
  3. Takusagawa, Y., Otagiri, M., Ui, S., Ohtsuki, T., Mimura, A., Ohkuma, M., Kudo, T.
    Purification and characterization of L-2,3-butanediol dehydrogenase of Brevibacterium saccharolyticum C-1012 expressed in Escherichia coli.
    Biosci. Biotechnol. Biochem. 65: 1876-1878 (2001). [PMID: 11577733]

[EC created 1972, modified 2010]