EC - 3(or 17)β-hydroxysteroid dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
3(or 17)β-hydroxysteroid dehydrogenase
Other names:
17β-hydroxy steroid dehydrogenase
3β-hydroxy steroid dehydrogenase
3β-hydroxysteroid dehydrogenase
β-hydroxy steroid dehydrogenase
Systematic name:
3(or 17)β-hydroxysteroid:NAD(P)+ oxidoreductase



Also acts on other 3β- or 17β-hydroxysteroids. cf. EC 3(or 17)α-hydroxysteroid dehydrogenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0035410 , GO:0030283
CAS Registry Number: 9015-81-0


  1. Dahm, K. and Breuer, H.
    Anreicherung einer 17β-hydroxysteroid:NAD(P)-oxydoreduktase aus der Nebenniere der Ratte.
    Hoppe-Seyler's Z. Physiol. Chem. 336 : 63-68 (1964).
  2. Lynn, W.S. and Brown, R.H.
    The conversion of progesterone to androgens by testes.
    J. Biol. Chem. 232 : 1015-1030 (1958).
  3. Marcus, P.I. and Talalay, P.
    Induction and purification of α- and β-hydroxysteroid dehydrogenases.
    J. Biol. Chem. 218 : 661-674 (1956).
  4. Schultz, R.M., Groman, F.V. and Engel, L.L.
    3(17)β-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.
    J. Biol. Chem. 252 : 3775-3783 (1977). [PMID: 193845]
  5. Talalay, P. and Dobson, M.M.
    Purification and properties of a α-hydroxysteroid dehydrogenase.
    J. Biol. Chem. 205 : 823-837 (1953).

[EC created 1961]