EC - 3α-hydroxysteroid 3-dehydrogenase (Si-specific)

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IntEnz Enzyme Nomenclature


Accepted name:
3α-hydroxysteroid 3-dehydrogenase (Si-specific)
Other names:
3α-hydroxysteroid oxidoreductase
hydroxyprostaglandin dehydrogenase
sterognost 3α
3α-hydroxysteroid dehydrogenase (B-specific)
3α-hydroxysteroid 3-dehydrogenase (B-specific)
3α-hydroxysteroid:NAD(P)+ 3-oxidoreductase (B-specific)
Systematic name:
3α-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Si-specific)



The enzyme acts on androsterone and other 3α-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC, 3α-hydroxysteroid 3-dehydrogenase (Re-specific).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00061
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047042
CAS Registry Number: 9028-56-2


  1. Jarabak, J. and Talalay, P.
    Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid hydrogenase.
    J. Biol. Chem. 235: 2147-2151 (1960). [PMID: 14406805]
  2. Kochakian, C.D., Carroll, B.R. and Uhri, B.
    Comparison of the oxidation of C19-hydroxy steroids by guinea pig liver homogenate.
    J. Biol. Chem. 224: 811-818 (1957). [PMID: 13405910]
  3. Marcus, P.I. and Talalay, P.
    Induction and purification of α- and β-hydroxysteroid dehydrogenases.
    J. Biol. Chem. 218: 661-674 (1956). [PMID: 13295221]
  4. Penning, T.M. and Sharp, R.B.
    Prostaglandin dehydrogenase activity of purified rat liver 3 α-hydroxysteroid dehydrogenase.
    Biochem. Biophys. Res. Commun. 148: 646-652 (1987). [PMID: 3479982]

[EC created 1961, modified 1986, modified 1990, modified 2012, modified 2013]