EC - Glucose-6-phosphate dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature


Accepted name:
glucose-6-phosphate dehydrogenase (NADP+)
Other names:
6-phosphoglucose dehydrogenase
D-glucose 6-phosphate dehydrogenase
Entner-Doudoroff enzyme
NADP-dependent glucose 6-phosphate dehydrogenase
NADP-glucose-6-phosphate dehydrogenase
glucose 6-phosphate dehydrogenase (NADP)
glucose-6-phosphate 1-dehydrogenase
glucose-6-phosphate dehydrogenase
Systematic name:
D-glucose-6-phosphate:NADP+ 1-oxidoreductase



The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC, glucose-6-phosphate dehydrogenase (NAD+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00067
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004345
CAS Registry Number: 9001-40-5
UniProtKB/Swiss-Prot: (75) [show] [UniProt]


  1. Glaser, L. and Brown, D.H.
    Purification and properties of D-glucose-6-phosphate dehydrogenase.
    J. Biol. Chem. 216 : 67-79 (1955). [PMID: 13252007]
  2. Julian, G.R., Wolfe, R.G. and Reithel, F.J.
    The enzymes of mammary gland. II. The preparation of glucose 6-phosphate dehydrogenase.
    J. Biol. Chem. 236 : 754-758 (1961). [PMID: 13790996]
  3. Noltmann, E.A., Gubler, C.J. and Kuby, S.A.
    Glucose 6-phosphate dehydrogenase (Zwischenferment). I. Isolation of the crystalline enzyme from yeast.
    J. Biol. Chem. 236 : 1225-1230 (1961). [PMID: 13729473]
  4. Engel, H.J., Domschke, W., Alberti, M. and Domagk, G.F.
    Protein structure and enzymatic activity. II. Purification and properties of a crystalline glucose-6-phosphate dehydrogenase from Candida utilis.
    Biochim. Biophys. Acta 191 : 509-516 (1969). [PMID: 5363983]
  5. Cho, S. W., Joshi, J. G.
    Characterization of glucose-6-phosphate dehydrogenase isozymes from human and pig brain.
    Neuroscience 38 : 819-828 (1990). [PMID: 2270145]
  6. Miclet, E., Stoven, V., Michels, P.A., Opperdoes, F.R., Lallemand, J.-Y. and Duffieux, F.
    NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase.
    J. Biol. Chem. 276 : 34840-34846 (2001). [PMID: 11457850]
  7. Iyer, R. B., Wang, J., Bachas, L. G.
    Cloning, expression, and characterization of the gsdA gene encoding thermophilic glucose-6-phosphate dehydrogenase from Aquifex aeolicus.
    Extremophiles 6 : 283-289 (2002). [PMID: 12215813]
  8. Hansen, T., Schlichting, B., Schonheit, P.
    Glucose-6-phosphate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima: expression of the g6pd gene and characterization of an extremely thermophilic enzyme.
    FEMS Microbiol. Lett. 216 : 249-253 (2002). [PMID: 12435510]
  9. Ibraheem, O., Adewale, I. O., Afolayan, A.
    Purification and properties of glucose 6-phosphate dehydrogenase from Aspergillus aculeatus.
    J. Biochem. Mol. Biol. 38 : 584-590 (2005). [PMID: 16202239]
  10. Olavarria, K., Valdes, D., Cabrera, R.
    The cofactor preference of glucose-6-phosphate dehydrogenase from Escherichia coli--modeling the physiological production of reduced cofactors.
    FEBS J. 279 : 2296-2309 (2012). [PMID: 22519976]

[EC created 1961, modified 2013, modified 2015]