EC 1 - Oxidoreductases
EC 1.1 - Acting on the CH-OH group of donors
EC 1.1.1 - With NAD+ or NADP+ as acceptor
EC 1.1.1.44 - Phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.1.1.44
Names
Accepted name:
phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
Other
names:
6-phospho-D-gluconate dehydrogenase
6-phosphogluconate dehydrogenase (decarboxylating)
6-phosphogluconic carboxylase
6-phosphogluconic dehydrogenase
phosphogluconic acid dehydrogenase
6PGD
6-phosphogluconate dehydrogenase (decarboxylating)
6-phosphogluconic carboxylase
6-phosphogluconic dehydrogenase
phosphogluconic acid dehydrogenase
6PGD
Systematic name:
6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
Reaction
- 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
Comments:
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ERGO
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00390
Gene Ontology:
GO:0004616
CAS Registry Number:
9073-95-4
References
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Direct oxidation of glucose-6-phosphate, 6-phosphogluconate and pentose-5-phosphate by enzymes of animal origin.Biochem. J. 50 : 81-95 (1951). [PMID: 14904376]
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Purification and properties of β-L-hydroxy acid dehydrogenase. II. Isolation of β-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis.J. Biol. Chem. 236 : 2975-2980 (1961). [PMID: 14487824]
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The oxidative pathway of carbohydrate metabolism in Escherichia coli. 1. The isolation and properties of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase.Biochem. J. 55 : 23-33 (1953). [PMID: 13093611]
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The oxidative pathway of carbohydrate metabolism in Escherichia coli. 5. Isolation and identification of ribulose phosphate produced from 6-phosphogluconate by the dehydrogenase of E. coli.Biochem. J. 65 : 686-689 (1957). [PMID: 13426085]
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Purification and properties of an NADP-specific 6-phosphogluconate dehydrogenase from Streptococcus faecalis.J. Biol. Chem. 250 : 6093-6100 (1975). [PMID: 238996]
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Kinetic studies of Haemophilus influenzae 6-phosphogluconate dehydrogenase.Biochim. Biophys. Acta 994 : 75-80 (1989). [PMID: 2783298]
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The Bacillus subtilis yqjI gene encodes the NADP+-dependent 6-P-gluconate dehydrogenase in the pentose phosphate pathway.J. Bacteriol. 186 : 4528-4534 (2004). [PMID: 15231785]
[EC 1.1.1.44 created 1961, modified 2013]