EC - Phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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IntEnz Enzyme Nomenclature


Accepted name:
phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
Other names:
6-phospho-D-gluconate dehydrogenase
6-phosphogluconate dehydrogenase (decarboxylating)
6-phosphogluconic carboxylase
6-phosphogluconic dehydrogenase
phosphogluconic acid dehydrogenase
Systematic name:
6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)



The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00390
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004616
CAS Registry Number: 9073-95-4
UniProtKB/Swiss-Prot: (63) [show] [UniProt]


  1. Dickens, F. and Glock, G.E.
    Direct oxidation of glucose-6-phosphate, 6-phosphogluconate and pentose-5-phosphate by enzymes of animal origin.
    Biochem. J. 50 : 81-95 (1951). [PMID: 14904376]
  2. Pontremoli, S., de Flora, A., Grazi, E., Mangiarotti, G., Bonsignore, A. and Horecker, B.L.
    Purification and properties of β-L-hydroxy acid dehydrogenase. II. Isolation of β-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis.
    J. Biol. Chem. 236 : 2975-2980 (1961). [PMID: 14487824]
  3. Scott, D.B.M. and Cohen, S.S.
    The oxidative pathway of carbohydrate metabolism in Escherichia coli. 1. The isolation and properties of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase.
    Biochem. J. 55 : 23-33 (1953). [PMID: 13093611]
  4. Scott, D.B.M. and Cohen, S.S.
    The oxidative pathway of carbohydrate metabolism in Escherichia coli. 5. Isolation and identification of ribulose phosphate produced from 6-phosphogluconate by the dehydrogenase of E. coli.
    Biochem. J. 65 : 686-689 (1957). [PMID: 13426085]
  5. Bridges, R. B., Palumbo, M. P., Wittenberger, C. L.
    Purification and properties of an NADP-specific 6-phosphogluconate dehydrogenase from Streptococcus faecalis.
    J. Biol. Chem. 250 : 6093-6100 (1975). [PMID: 238996]
  6. Yoon, H., Anderson, C. D., Anderson, B. M.
    Kinetic studies of Haemophilus influenzae 6-phosphogluconate dehydrogenase.
    Biochim. Biophys. Acta 994 : 75-80 (1989). [PMID: 2783298]
  7. Zamboni, N., Fischer, E., Laudert, D., Aymerich, S., Hohmann, H. P., Sauer, U.
    The Bacillus subtilis yqjI gene encodes the NADP+-dependent 6-P-gluconate dehydrogenase in the pentose phosphate pathway.
    J. Bacteriol. 186 : 4528-4534 (2004). [PMID: 15231785]

[EC created 1961, modified 2013]