EC - Plant 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating)

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IntEnz Enzyme Nomenclature


Accepted name:
plant 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating)
Other names:
3β-HSD/D1 (gene name)
3β-HSD/D2 (gene name)
3β-hydroxysteroid dehydrogenases/C-4 decarboxylase [ambiguous]
Systematic name:
3β-hydroxysteroid-4α-carboxylate:NAD+ 3-oxidoreductase (decarboxylating)



The enzyme, found in plants, catalyses multiple reactions during plant sterol biosynthesis. Unlike the fungal/animal enzyme EC, 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating), the plant enzyme is specific for NAD+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102191


  1. Rondet, S., Taton, M., Rahier, A.
    Identification, characterization, and partial purification of 4 alpha-carboxysterol-C3-dehydrogenase/ C4-decarboxylase from Zea mays.
    Arch. Biochem. Biophys. 366 : 249-260 (1999). [PMID: 10356290]
  2. Rahier, A., Darnet, S., Bouvier, F., Camara, B., Bard, M.
    Molecular and enzymatic characterizations of novel bifunctional 3beta-hydroxysteroid dehydrogenases/C-4 decarboxylases from Arabidopsis thaliana.
    J. Biol. Chem. 281 : 27264-27277 (2006). [PMID: 16835224]
  3. Rahier, A., Bergdoll, M., Genot, G., Bouvier, F., Camara, B.
    Homology modeling and site-directed mutagenesis reveal catalytic key amino acids of 3beta-hydroxysteroid-dehydrogenase/C4-decarboxylase from Arabidopsis.
    Plant Physiol. 149 : 1872-1886 (2009). [PMID: 19218365]

[EC created 2019]