EC 1.1.1.413 - A-factor type γ-butyrolactone 1'-reductase (1S-forming)

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IntEnz Enzyme Nomenclature
EC 1.1.1.413

Names

Accepted name:
A-factor type γ-butyrolactone 1'-reductase (1S-forming)
Other name:
barS1 (gene name)
Systematic name:
(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one:NADP+ 1'-oxidoreductase

Reaction

Comments:

The enzyme, which is found in bacteria that produce virginiae-butanolide (VB) type γ-butyrolactone autoregulators, reduces its substrate stereospecifically, forming a hydroxyl group in the (S) configuration.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Shikura, N., Yamamura, J., Nihira, T.
    barS1, a gene for biosynthesis of a gamma-butyrolactone autoregulator, a microbial signaling molecule eliciting antibiotic production in Streptomyces species.
    J. Bacteriol. 184: 5151-5157 (2002). [PMID: 12193632]

[EC 1.1.1.413 created 2017]