EC 1.1.1.396 - Bacteriochlorophyllide-a dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.396

Names

Accepted name:
bacteriochlorophyllide-a dehydrogenase
Other name:
bchC (gene name)
Systematic name:
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming)

Reactions

Comments:

The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme oxidizes a hydroxyl group on ring A, converting it to an oxo group.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Wellington, C. L., Beatty, J. T.
    Promoter mapping and nucleotide sequence of the bchC bacteriochlorophyll biosynthesis gene from Rhodobacter capsulatus.
    Gene 83 : 251-261 (1989). [PMID: 2555268]
  2. McGlynn, P., Hunter, C. N.
    Genetic analysis of the bchC and bchA genes of Rhodobacter sphaeroides.
    Mol. Gen. Genet. 236 : 227-234 (1993). [PMID: 8437569]
  3. Lange, C., Kiesel, S., Peters, S., Virus, S., Scheer, H., Jahn, D., Moser, J.
    Broadened Substrate Specificity of 3-Hydroxyethyl Bacteriochlorophyllide a Dehydrogenase (BchC) Indicates a New Route for the Biosynthesis of Bacteriochlorophyll a.
    J. Biol. Chem. 290 : 19697-19709 (2015). [PMID: 26088139]

[EC 1.1.1.396 created 2016]