EC 1.1.1.393 - 3β-hydroxycholanate 3-dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature
EC 1.1.1.393

Names

Accepted name:
3β-hydroxycholanate 3-dehydrogenase (NADP+)
Other name:
3β-hydroxysteroid dehydrogenase [ambiguous]
Systematic name:
isolithocholate:NADP+ 3-oxidoreductase

Reaction

Comments:

This bacterial enzyme is involved, along with EC 1.1.1.52, 3α-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3α-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3β-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.391, 3β-hydroxycholanate 3-dehydrogenase (NAD+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Akao, T., Akao, T., Hattori, M., Namba, T., Kobashi, K.
    3 beta-Hydroxysteroid dehydrogenase of Ruminococcus sp. from human intestinal bacteria.
    J. Biochem. 99 : 1425-1431 (1986). [PMID: 3458705]
  2. Devlin, A. S., Fischbach, M. A.
    A biosynthetic pathway for a prominent class of microbiota-derived bile acids.
    Nat. Chem. Biol. 11 : 685-690 (2015). [PMID: 26192599]

[EC 1.1.1.393 created 2016]