EC 1.1.1.383 - Ketol-acid reductoisomerase [NAD(P)+]

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IntEnz Enzyme Nomenclature
EC 1.1.1.383

Names

Accepted name:
ketol-acid reductoisomerase [NAD(P)+]
Systematic name:
(2R)-2,3-dihydroxy-3-methylbutanoate:NAD(P)+ oxidoreductase (isomerizing)

Reaction

Comments:

The enzyme, characterized from the bacteria Hydrogenobaculum sp. and Syntrophomonas wolfei subsp. wolfei and from the archaea Metallosphaera sedula and Ignisphaera aggregans, can use both NADH and NADPH with similar efficiency [cf. EC 1.1.1.86, ketol-acid reductoisomerase (NADP+) and EC 1.1.1.382, ketol-acid reductoisomerase (NAD+)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Brinkmann-Chen, S., Cahn, J. K., Arnold, F. H.
    Uncovering rare NADH-preferring ketol-acid reductoisomerases.
    Metab. Eng. 26C : 17-22 (2014). [PMID: 25172159]

[EC 1.1.1.383 created 2015]