IntEnz

EC 1.1.1.381 - 3-hydroxy acid dehydrogenase

IntEnz Enzyme Nomenclature
EC 1.1.1.381

Names

Reaction

• 43524 [IUBMB]
  L-allo-threonine

  L-allo-threonine

  Name origin: UniProt - CHECKED (C)

  CHEBI:58585

  Formula: C4H9NO3
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NADP⁺

  NADP(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:58349

  Formula: C21H25N7O17P3
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  =

  aminoacetone

  aminoacetone

  Name origin: UniProt - CHECKED (C)

  CHEBI:58320

  Formula: C3H8NO
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  CO₂

  CO2

  Name origin: UniProt - CHECKED (C)

  CHEBI:16526

  Formula: CO2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NADPH

  NADPH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57783

  Formula: C21H26N7O17P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

Comments:

The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from E. coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase).

Links to other databases

References

1. Fujisawa, H., Nagata, S., Misono, H.
   Characterization of short-chain dehydrogenase/reductase homologues of Escherichia coli (YdfG) and Saccharomyces cerevisiae (YMR226C).
   Biochim. Biophys. Acta 1645 : 89-94 (2003). [PMID: 12535615]

[EC 1.1.1.381 created 2014]