EC 1.1.1.381 - 3-hydroxy acid dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.381

Names

Accepted name:
3-hydroxy acid dehydrogenase
Other names:
ydfG (gene name)
YMR226c (gene name)
Systematic name:
L-allo-threonine:NADP+ 3-oxidoreductase

Reactions

Comments:

The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from E. coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Fujisawa, H., Nagata, S., Misono, H.
    Characterization of short-chain dehydrogenase/reductase homologues of Escherichia coli (YdfG) and Saccharomyces cerevisiae (YMR226C).
    Biochim. Biophys. Acta 1645 : 89-94 (2003). [PMID: 12535615]

[EC 1.1.1.381 created 2014]