EC 1 - Oxidoreductases
EC 1.1 - Acting on the CH-OH group of donors
EC 1.1.1 - With NAD+ or NADP+ as acceptor
EC 1.1.1.38 - Malate dehydrogenase (oxaloacetate-decarboxylating)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.1.1.38
Names
Accepted name:
malate dehydrogenase (oxaloacetate-decarboxylating)
Other
names:
malic enzyme
[ambiguous]
NAD-linked malic enzyme [ambiguous]
NAD-malic enzyme
NAD-specific malic enzyme
pyruvic-malic carboxylase
NAD-linked malic enzyme [ambiguous]
NAD-malic enzyme
NAD-specific malic enzyme
pyruvic-malic carboxylase
Systematic name:
(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)
Reactions
- (1) (S)-malate + NAD+ = pyruvate + CO2 + NADH
- (2) oxaloacetate = pyruvate + CO2
Comments:
Unlikef EC 1.1.1.39, malate dehydrogenase (decarboxylating), this enzyme can also decarboxylate oxaloacetate. cf. EC 1.1.1.40, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+).
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ERGO
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00294
Gene Ontology:
GO:0004471
,
GO:0008948
CAS Registry Number:
9080-52-8
References
-
Biosynthesis of dicarboxylic acids by carbon dioxide fixation. V. Further studies of the "malic" enzyme of Lactobacillus arabinosus.J. Biol. Chem. 192 : 301-312 (1951). [PMID: 14917678]
-
Studies on regulatory functions of malic enzymes. IV. Effects of sulfhydryl group modification on the catalytic function of NAD-linked malic enzyme from Escherichia coli.J. Biochem. 86 : 325-333 (1979). [PMID: 225306]
[EC 1.1.1.38 created 1961]