EC - Malate dehydrogenase (oxaloacetate-decarboxylating)

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IntEnz Enzyme Nomenclature


Accepted name:
malate dehydrogenase (oxaloacetate-decarboxylating)
Other names:
malic enzyme [ambiguous]
NAD-linked malic enzyme [ambiguous]
NAD-malic enzyme
NAD-specific malic enzyme
pyruvic-malic carboxylase
Systematic name:
(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)



Unlikef EC, malate dehydrogenase (decarboxylating), this enzyme can also decarboxylate oxaloacetate. cf. EC, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00294
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004471 , GO:0008948
CAS Registry Number: 9080-52-8
UniProtKB/Swiss-Prot: (120) [show] [UniProt]


  1. Kaufman, S., Korkes, S. and del Campillo, A.
    Biosynthesis of dicarboxylic acids by carbon dioxide fixation. V. Further studies of the "malic" enzyme of Lactobacillus arabinosus.
    J. Biol. Chem. 192 : 301-312 (1951). [PMID: 14917678]
  2. Yamaguchi, M.
    Studies on regulatory functions of malic enzymes. IV. Effects of sulfhydryl group modification on the catalytic function of NAD-linked malic enzyme from Escherichia coli.
    J. Biochem. 86 : 325-333 (1979). [PMID: 225306]

[EC created 1961]