EC 1.1.1.379 - (R)-mandelate dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.379

Names

Accepted name:
(R)-mandelate dehydrogenase
Other names:
ManDH2
D-ManDH2
D-mandelate dehydrogenase [ambiguous]
Systematic name:
(R)-mandelate:NAD+ 2-oxidoreductase

Reaction

Comments:

The enzyme, found in bacteria and fungi, can also accept a number of substituted mandelate derivatives, such as 3-hydroxymandelate, 4-hydroxymandelate, 2-methoxymandelate, 4-hydroxy-3-methoxymandelate and 3-hydroxy-4-methoxymandelate. The enzyme has no activity with (S)-mandelate (cf. EC 1.1.99.31, (S)-mandelate dehydrogenase) [1,2]. The enzyme transfers the pro-R hydrogen from NADH [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Baker, D.P. and Fewson, C.A.
    Purification and characterization of D(-)-mandelate dehydrogenase from Rhodotorula graminis.
    Microbiology 135: 2035-2044 (1989).
  2. Baker, D. P., Kleanthous, C., Keen, J. N., Weinhold, E., Fewson, C. A.
    Mechanistic and active-site studies on D(--)-mandelate dehydrogenase from Rhodotorula graminis.
    Biochem. J. 281: 211-218 (1992). [PMID: 1731758]

[EC 1.1.1.379 created 2014]