EC - Malate dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
malate dehydrogenase
Other names:
L-malate dehydrogenase
L-malate-NAD+ oxidoreductase
NAD-L-malate dehydrogenase
NAD-dependent malate dehydrogenase
NAD-dependent malic dehydrogenase
NAD-linked malate dehydrogenase
NAD-malate dehydrogenase
NAD-malic dehydrogenase
NAD-specific malate dehydrogenase
malate (NAD) dehydrogenase
malic acid dehydrogenase
malic dehydrogenase
Systematic name:
(S)-malate:NAD+ oxidoreductase



Also oxidizes some other 2-hydroxydicarboxylic acids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00066
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030060
CAS Registry Number: 9001-64-3
UniProtKB/Swiss-Prot: (596) [show] [UniProt]


  1. Banaszak, L.J. and Bradshaw, R.A.
    Malate dehydrogenase.
    In: Boyer, P.D. (Ed.) The Enzymes , 3rd ed. vol. 11 , Academic Press , New York , 1975 , 369-396
  2. Guha, A., Englard, S. and Listowsky, I.
    Beef heart malic dehydrogenases. VII. Reactivity of sulfhydryl groups and conformation of the supernatant enzyme.
    J. Biol. Chem. 243 : 609-615 (1968). [PMID: 5637713]
  3. McReynolds, M.S. and Kitto, G.B.
    Purification and properties of Drosophila malate dehydrogenases.
    Biochim. Biophys. Acta 198 : 165-175 (1970). [PMID: 4313528]
  4. Wolfe, R.G. and Nielands, J.B.
    Some molecular and kinetic properties of heart malic dehydrogenase.
    J. Biol. Chem. 221 : 61-69 (1956).

[EC created 1961]