EC 1.1.1.369 - D-chiro-inositol 1-dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.369

Names

Accepted name:
D-chiro-inositol 1-dehydrogenase
Other names:
DCI 1-dehydrogenase
IolG
Systematic name:
1D-chiro-inositol:NAD+ 1-oxidoreductase

Reaction

Comments:

The enzyme, found in the bacterium Bacillus subtilis, also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. It shows trace activity with D-ribose and D-fructose [1]. It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Ramaley, R., Fujita, Y., Freese, E.
    Purification and properties of Bacillus subtilis inositol dehydrogenase.
    J. Biol. Chem. 254 : 7684-7690 (1979). [PMID: 112095]
  2. Yoshida, K., Yamaguchi, M., Morinaga, T., Ikeuchi, M., Kinehara, M., Ashida, H.
    Genetic modification of Bacillus subtilis for production of D-chiro-inositol, an investigational drug candidate for treatment of type 2 diabetes and polycystic ovary syndrome.
    Appl. Environ. Microbiol. 72 : 1310-1315 (2006). [PMID: 16461681]

[EC 1.1.1.369 created 2014]