IntEnz

EC 1.1.1.369 - D-chiro-inositol 1-dehydrogenase

IntEnz Enzyme Nomenclature
EC 1.1.1.369

Names

Reaction

• 25832 [IUBMB]
  1D-chiro-inositol

  1D-chiro-inositol

  Name origin: UniProt - CHECKED (C)

  CHEBI:27372

  Formula: C6H12O6
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  NAD⁺

  NAD(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:57540

  Formula: C21H26N7O14P2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  =

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  NADH

  NADH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57945

  Formula: C21H27N7O14P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  scyllo-inosine

  scyllo-inosine

  Name origin: UniProt - CHECKED (C)

  CHEBI:50920

  Formula: C6H10O6
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

Comments:

The enzyme, found in the bacterium Bacillus subtilis, also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. It shows trace activity with D-ribose and D-fructose [1]. It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.

Links to other databases

References

1. Ramaley, R., Fujita, Y., Freese, E.
   Purification and properties of Bacillus subtilis inositol dehydrogenase.
   J. Biol. Chem. 254 : 7684-7690 (1979). [PMID: 112095]
2. Yoshida, K., Yamaguchi, M., Morinaga, T., Ikeuchi, M., Kinehara, M., Ashida, H.
   Genetic modification of Bacillus subtilis for production of D-chiro-inositol, an investigational drug candidate for treatment of type 2 diabetes and polycystic ovary syndrome.
   Appl. Environ. Microbiol. 72 : 1310-1315 (2006). [PMID: 16461681]

[EC 1.1.1.369 created 2014]