EC 1 - Oxidoreductases
EC 1.1 - Acting on the CH-OH group of donors
EC 1.1.1 - With NAD+ or NADP+ as acceptor
EC 1.1.1.363 - Glucose-6-phosphate dehydrogenase [NAD(P)+]
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 1.1.1.363
Names
Accepted name:
glucose-6-phosphate dehydrogenase [NAD(P)+]
Other
names:
G6PDH
G6PD
Glc6PD
G6PD
Glc6PD
Systematic name:
D-glucose-6-phosphate:NAD(P)+ 1-oxidoreductase
Reactions
-
15841 [IUBMB]D-glucose 6-phosphateName origin: UniProt - CHECKED (C)Formula: C6H11O9P
Charge: -2ChEBI compound status: CHECKED (C)NADP+Name origin: UniProt - CHECKED (C)Formula: C21H25N7O17P3
Charge: -3ChEBI compound status: CHECKED (C)=6-phospho-D-glucono-1,5-lactoneName origin: UniProt - CHECKED (C)Formula: C6H9O9P
Charge: -2ChEBI compound status: CHECKED (C)H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C) -
38215 [IUBMB]D-glucose 6-phosphateName origin: UniProt - CHECKED (C)Formula: C6H11O9P
Charge: -2ChEBI compound status: CHECKED (C)NAD+Name origin: UniProt - CHECKED (C)Formula: C21H26N7O14P2
Charge: -1ChEBI compound status: CHECKED (C)=6-phospho-D-glucono-1,5-lactoneName origin: UniProt - CHECKED (C)Formula: C6H9O9P
Charge: -2ChEBI compound status: CHECKED (C)H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)
Comments:
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the Gram-positive bacterium Leuconostoc mesenteroides prefers NADP+ while the enzyme from the Gram-negative bacterium Gluconacetobacter xylinus prefers NAD+. cf. EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+) and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).
Links to other databases
UniProtKB/Swiss-Prot:
G6PD_LEUME
G6PD_PSEAE
G6PE-2_HUMAN
G6PE_HUMAN
G6PE_MOUSE
G6PE_RABIT
References
-
Glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. Kinetic studies.J. Biol. Chem. 246 : 2047-2057 (1971). [PMID: 4396688]
-
Lysine-21 of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase participates in substrate binding through charge-charge interaction.Protein Sci. 1 : 329-334 (1992). [PMID: 1304341]
-
On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.Biochemistry 37 : 2759-2767 (1998). [PMID: 9485426]
-
Purification and characterization of the NAD-preferring glucose 6-phosphate dehydrogenase from Acetobacter hansenii (Acetobacter xylinum).Arch. Biochem. Biophys. 310 : 360-366 (1994). [PMID: 8179320]
[EC 1.1.1.363 created 2013, modified 2015]