IntEnz

EC 1.1.1.363 - Glucose-6-phosphate dehydrogenase [NAD(P)⁺]

IntEnz Enzyme Nomenclature
EC 1.1.1.363

Names

Reactions

• 15841 [IUBMB]
  D-glucose 6-phosphate

  D-glucose 6-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:61548

  Formula: C6H11O9P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  NADP⁺

  NADP(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:58349

  Formula: C21H25N7O17P3
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  =

  6-phospho-D-glucono-1,5-lactone

  6-phospho-D-glucono-1,5-lactone

  Name origin: UniProt - CHECKED (C)

  CHEBI:57955

  Formula: C6H9O9P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  NADPH

  NADPH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57783

  Formula: C21H26N7O17P3
  Charge: -4

  ChEBI compound status: CHECKED (C)

  
• 38215 [IUBMB]
  D-glucose 6-phosphate

  D-glucose 6-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:61548

  Formula: C6H11O9P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  NAD⁺

  NAD(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:57540

  Formula: C21H26N7O14P2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  =

  6-phospho-D-glucono-1,5-lactone

  6-phospho-D-glucono-1,5-lactone

  Name origin: UniProt - CHECKED (C)

  CHEBI:57955

  Formula: C6H9O9P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  NADH

  NADH

  Name origin: UniProt - CHECKED (C)

  CHEBI:57945

  Formula: C21H27N7O14P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the Gram-positive bacterium Leuconostoc mesenteroides prefers NADP+ while the enzyme from the Gram-negative bacterium Gluconacetobacter xylinus prefers NAD+. cf. EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+) and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).

Links to other databases

References

1. Olive, C., Geroch, M. E., Levy, H. R.
   Glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. Kinetic studies.
   J. Biol. Chem. 246 : 2047-2057 (1971). [PMID: 4396688]
2. Lee, W. T., Levy, H. R.
   Lysine-21 of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase participates in substrate binding through charge-charge interaction.
   Protein Sci. 1 : 329-334 (1992). [PMID: 1304341]
3. Cosgrove, M. S., Naylor, C., Paludan, S., Adams, M. J., Levy, H. R.
   On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.
   Biochemistry 37 : 2759-2767 (1998). [PMID: 9485426]
4. Ragunathan, S., Levy, H. R.
   Purification and characterization of the NAD-preferring glucose 6-phosphate dehydrogenase from Acetobacter hansenii (Acetobacter xylinum).
   Arch. Biochem. Biophys. 310 : 360-366 (1994). [PMID: 8179320]

[EC 1.1.1.363 created 2013, modified 2015]