EC 1.1.1.362 - Aklaviketone reductase

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IntEnz Enzyme Nomenclature
EC 1.1.1.362

Names

Accepted name:
aklaviketone reductase
Other names:
dauE (gene name)
aknU (gene name)
Systematic name:
aklavinone:NADP+ oxidoreductase

Reaction

Comments:

The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Dickens, M. L., Ye, J., Strohl, W. R.
    Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.
    J. Bacteriol. 178: 3384-3388 (1996). [PMID: 8655529]

[EC 1.1.1.362 created 2013]